Products & ReviewLife Sciences
LY294002
PI3K/AKT pathway inhibitor; Inhibits PI3K
LY294002
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LY294002 is a PI3K inhibitor that has greater potency and selectivity than quercetin, the structure on which it is based. LY294002 inhibits PI3K (IC₅₀ = 1.4 µM) and also shows activity against CK2, but not PI4K, EGFR, PDGFR, MAPK, PKA, or PKC. (Davies et al., Vlahos et al.)
MAINTENANCE AND SELF-RENEWAL
- Suppresses proliferation and self-renewal of mouse embryonic stem (ES) cells (Lianguzova et al., Paling et al.).
DIFFERENTIATION
- Promotes differentiation to insulin-producing cells from mouse ES cells (Hori et al.).
- Inhibits myotube formation from myoblasts (Coolican et al., Jiang et al.).
