MicroCal PEAQ-ITC Automated
High productivity measurement of multiple binding parameters.
MicroCal PEAQ-ITC Automated
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Great outcomes It is at the core of my study.
Analyze Binding interactions of lectin-glycopeptides
I am obtaining the thermodynamic parameters for my research utilizing Malvern's very sensitive ITC equipment. I was able to produce findings of a very high caliber, and Malvern's PEAQ ITC program is fantastic; I adore it. Although it is difficult to analyze the samples because many precautions must be taken, it is acceptable because we are only interested in binding affinities that are micromolar or lower because everything counts at that point. Additionally, customer support is excellent. Whenever I write about a problem, I always receive a response within 24 hours.
Review Date: 19 May 2023 | Malvern Panalytical
From less amount of sample can determine the interaction studies
Binding interaction studies
Malvern Microcal PEAQ-ITC Automated system is very easy to use. I love this instrument very much. Software for analysis is also very easy to determine the binding interaction studies.
Review Date: 10 Feb 2023 | Malvern Panalytical
Manufacturer's Response
Thank you so much for taking the time to send in the review. It was very kind of you. The development team put a lot of work into making the user experience and enjoyable one and will be so pleased to hear that you 'love it'.
We got excellent results and we were able to get some good publications.
Protein drug binding
When we started the protein-drug binding study, we were had the impression 'How do we handle and interpret the data?', but as we went along it was very convenient to perform the experiment and do data analysis. I have been using this machine since my Ph.D. days. It has undergone huge modifications and advances. Excellent instrument !
Review Date: 8 Dec 2020 | Malvern Panalytical
Manufacturer's Response
Thank you for your kind words. The instrument was designed with protein-drug interactions in mind and so it was hugely gratifying to hear that it supported your research in that important field. Thanks again.
Very good instrument, fast and easy to use.
Binding experiments with macromolecules (proteins, peptides)
The instrument is very easy to use, there are videos demonstrating everything you need to use it. Loading is a bit difficult, but because it uses very little material it is not a huge deal to miss a few injections until you get used to loading efficiently. In one day it is possible to get 5 or 6 experiments done, if not more - so very fast compared to other ITC instruments. I find it very reproducible as well. I am overall very happy with the instrument, since I was able to obtain data in a really short time, including binding and kinetic experiments. The only issue I have with it is that the service contract is on the expensive side. It is possible to do routine maintenance without service (there are also videos for that), and Malvern has good phone technical service so overall it is not a major set back since most service contracts are expensive.
Review Date: 31 Jan 2017 | Malvern Panalytical
Manufacturer's Response
Thank you very much for your feedback
The MicroCal PEAQ-ITC Automated is a configurable, low volume, highly sensitive isothermal titration calorimeter which offers the convenience of unattended operation. It delivers direct, label-free in solution measurement of all binding parameters in a single experiment. Applications include characterizing molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules. It can also be used to measure enzyme kinetics.
The system directly measures heat released or absorbed during biochemical binding events, from which it calculates binding affinity (KD), stoichiometry (n), enthalpy (ΔH), and entropy (ΔS). Other than preparing samples and reagents to appropriate concentrations, there is minimal assay development and time to first result is fast. Easy-to use software includes optimized automation scripts for robust operation with a variety of sample types and conditions.
Features:
- User-friendly design tools assist in selecting experimental run parameters.
- All binding parameters (affinity, stoichiometry, enthalpy and entropy) in a single experiment.
- Quick to first result with minimal assay development, no labelling, no immobilization and no molecular weight limitations.
- High signal to noise gives more confidence in accessing data quality and relevance of generated affinity and thermodynamic parameters.
- Outstanding data quality for sub-millimolar to picomolar disassociation constants (10-2 to 10-12 M).
- Coin shaped cell optimizes sample mixing.
- Nonreactive Hastelloy for chemical resistance and compatibility with biological samples.
- Sensitivity to investigate any biomolecular interaction using as little as 10µg of protein.
- Samples presented in temperature controlled 96-well plate.
- Fully automated system with walk-away operation for enhanced productivity.
