Products & ReviewLife Sciences
Pifithrin-mu
p53 inhibitor
Pifithrin-mu
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Pifithrin-mu (PFT-µ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondrial surface, without affecting p53 transactivational activities (Strom et al.). In vitro, PFT-µ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM; Hagn et al.).
MAINTENANCE AND SELF-RENEWAL
- In combination with Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor Y-27632, improves cell recovery after cryopreservation (Xu et al.).
- Inhibits DNA damage-induced apoptosis in human embryonic stem cells (Qin et al.).
