Products & ReviewLife Sciences
PluriSIn-1
Oleic acid biosynthesis pathway inhibitor; Inhibits stearoyl-CoA desaturase (SCD1)
PluriSIn-1
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PluriSIn-1 is an N-acyl phenylhydrazine derivative that inhibits stearoyl-CoA desaturase, a key enzyme for lipid metabolism that is expressed in human pluripotent stem cells (Ben-David et al.).
DIFFERENTIATION
- Selectively eliminates undifferentiated human embryonic stem (ES) and induced pluripotent stem (iPS) cells while sparing differentiated cells, and prevents teratoma formation in transplanted mice (Ben-David et al.).
- Induces apoptosis of Nanog-positive iPS cells in vitro, while leaving iPS cell-derived cardiomyocytes unaffected (Zhang et al.).
