Pressure Arteriography System

Pressure arteriography is the gold-standard for quantifying function, reactivity and mechanics in isolated perfused blood vessels. When embarking on pressure arteriography, many factors warrant consideration. In addition to the requisite surgical skills for isolating and cannulating small arteries, proper instrumentation is also paramount. Pressure arteriography, while a powerful tool, comprises a number of different hardware and software components that must integrate and operate properly.

Living Systems Instrumentation is the only provider for complete pressure arteriography systems that not only allow the researcher to quickly get their experiments up and running, but ensures the quality and reproducibility of the data collected. Not only is LSI a pioneer in pressure arteriography, they also have a long and comprehensive publication history that speaks to their established and state-of-the-art arteriography systems.

While there are other options for individual arteriograph components available from various sources, these require significant investment in time to optimize, refine and “debug” that delays maintaining a regular experiment schedule and often lack the robustness required for data integrity and confidence.

And with their long experiential history and comprehensive knowledge base, Living Systems is always available to assist and support all of your arteriography needs.

Constant Pressure

• The vast majority of applications are well-served by constant pressure, no intraluminal flow setup
• Distal end of vessel is occluded
• Key components include a pressure source, vessel chamber, means for temperature control, and data acquisition hardware/software

Constant Pressure & Flow

• Setup for intravascular flow is a bit more complex
• Distal end of vessel remains open
• In addition to the basic items for regulating intravascular pressure, you will also need a pump to control intraluminal solution flow and a way to monitor pressure on both sides of the cannulated vessel

Parts of a Pressure Arteriography

• Vessel is mounted between the cannulae and tied in place with nylon thread (provided with the chamber)
• Cannulae provide access to the lumen of the vessel
• Blood is flushed out of the vessel
• Superfusion of desired buffer into chamber and into vessel