Products & ReviewLife Sciences
Prostaglandin E2
Prostanoid pathway activator; Activates prostaglandin receptors EP1, EP2, EP3 and EP4
Prostaglandin E2
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Prostaglandin Eâ‚‚ (PGEâ‚‚) is the most biologically active and well-studied prostaglandin. It binds with very high affinity to the EP1, EP2, EP3, and EP4 receptors (Ki = 9.1, 4.9, 0.33, 0.79 nM respectively). (Abramovitz et al., Bos et al.)
MAINTENANCE AND SELF-RENEWAL
- Required for the development of hematopoietic stem cells (HSCs) in mice and zebrafish (North et al.).
- Improves engraftment of mouse HSCs, possibly through increasing homing, survival, and/or self-renewal (Hoggatt et al. 2009, Hoggatt et al. 2013, North et al.).
DIFFERENTIATION
- Promotes differentiation of hematopoietic progenitor cells from mouse, macaque, and human embryonic stem cells (Gori et al., North et al., Woods et al.).
- Promotes differentiation of myeloid-derived suppressor cells from hematopoietic progenitors (Sinha et al.).
- Promotes differentiation of Th17 cells from naí¯ve T-cells (Boniface et al.).
