Products & ReviewLife Sciences
Quercetin
mTOR, PI3K/AKT, NF-kB, and tyrosine kinase pathway inhibitor; Inhibits PI3K and SRC kinases
Quercetin
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Quercetin inhibits phosphoinositide 3-kinase isoforms (beta: IC50 = 5.4 µM, gamma: IC50 = 2.4 µM, delta: IC50 = 3.0 µM) and SRC kinases but only shows slight inhibitory activity against serine/threonine kinases ERK1/2 and p38 alpha, as well as protein kinase C (Navarro-Nunez et al.).
REPROGRAMMING
- Stimulates glycolytic metabolism and promotes reprogramming of somatic cells (Zhang et al.).
- Enhances reprogramming of human primary somatic cells to induced pluripotent stem cells (Zhu et al.).
CANCER RESEARCH
- Induces hypoxia-inducible factor-1α (HIF-1α) and inhibits cell proliferation (Triantafyllou et al.).
- Promotes apoptosis of glioblastoma cells when used together with temozolomide (Sang et al.).
- Reduces tumorigenicity of pancreatic cancer cells (Fan et al.).
