Rag1 Knockout Rat
Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes. Rag1 Knockout Rat Characteristics: 29 bp deletion within Exon 2 on chromosome 3 Homozygous Rag1 knockout rats display loss of RAG1 protein via Wester…
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Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.
Rag1 Knockout Rat Characteristics:
- 29 bp deletion within Exon 2 on chromosome 3
- Homozygous Rag1 knockout rats display loss of RAG1 protein via Western blot
- Homozygous Rag1 knockout rats show loss of B and T cells by FACS analysis
- Background Strain: Sprague-Dawley
Research Applications:
- Xenograft
- Cancer metastasis
- Vaccine development
- Inflammation/Autoimmune disorders
- Thrombosis/Cardiac fibrosis
- Vascular defects
