Products & ReviewLife Sciences
Raloxifene
Selective estrogen receptor modulator
Raloxifene (Hydrochloride)
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Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits agonistic (estrogenic) activity in bone cells without stimulating ER activity in breast or uterine tissues (Black et al.).
DIFFERENTIATION
- Enhances osteoblast differentiation in mouse bone marrow and human osteoblast cultures (Qu et al.; Viereck et al.).
- Inhibits osteoclast differentiation in primary human bone marrow mononuclear cell cultures (Ramalho et al.).
- Reduced endodermal differentiation (HNF-4α expression) in embryoid bodies derived from human embryonic stem (ES) cells (Kim et al.).
