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RG108
Epigenetic modifier; Inhibits DNA methyltransferase (DNMT)
RG108
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RG108 is an epigenetic modifier that inhibits DNA methyltransferase (IC₅₀ = 115 nM). RG108 is a non-nucleoside inhibitor that acts by direct binding to the methyltransferase enzyme whereby it blocks the enzyme active site. (Brueckner et al., Stresemann et al.)
REPROGRAMMING
- Enhances reprogramming efficiency of human and mouse somatic cells to induced pluripotent stem (iPS) cells (Mali et al., Pasha et al., Shi et al.).
