RNA Polymerase II Toolbox
RNA polymerase II features a large carboxyl-terminal repeat domain (CTD) that consists of the consensus heptapeptide Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Differential phosphorylation in this CTD orchestrates accessibility for various co-factors of the transcription complex. Using the phosphorylation specific antibodies it is now possible to determine specific phosphorylation states. In addition to phosphorylation specific antib…
The supplier does not provide quotations for this product through SelectScience. You can search for similar products in our Product Directory.
RNA polymerase II features a large carboxyl-terminal repeat domain (CTD) that consists of the consensus heptapeptide Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Differential phosphorylation in this CTD orchestrates accessibility for various co-factors of the transcription complex. Using the phosphorylation specific antibodies it is now possible to determine specific phosphorylation states.
In addition to phosphorylation specific antibodies against the Serines 2, 5 and 7 we will soon also offer phosphorylation specific antibodies against Tyrosine 1 and Threonine 4.
Also availbale is RNA Pol II CTD antibody 1C7, which recognizes an unphosphorylated epitope in the CTD.
Taken together, this is the most comprehensive set of phosphorylation specific anitbodies to the CTD of RNA polymerase II.
