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SB202190
p38 MAPK inhibitor
SB202190
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SB202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively (Davies et al.; Jiang et al.). As a pyridinyl imidazole inhibitor, SB202190 directly binds p38 MAP kinases in the ATP binding pocket (Fox et al.).
MAINTENANCE AND SELF-RENEWAL
- Improves the self-renewal ability of neural stem cells from NPC1-deficient mice (Yang et al.).
- Blocks adiponectin-mediated proliferation of hematopoietic stem cells (DiMascio et al.).
- Reduces BMP3-mediated proliferation of C3H10T1/2 mesenchymal stem cells (Stewart et al.).
DIFFERENTIATION
- Induces cardiomyocyte differentiation from human embryonic stem cells (Graichen et al.).
