SB203580

SB203580 (Hydrochloride) is a potent inhibitor of p38 MAPK activity (IC₅₀ = 0.6 µM). It inhibits both the α and β isoforms of p38 MAPK, and does not inhibit ERK or JNK. (Bain et al., Cuenda et al.)

MAINTENANCE AND SELF-RENEWAL

• Enhances the growth and self-renewal of mouse embryonic stem (ES) cells (Qi et al.).
• Promotes long-term maintenance of human naí¯ve ground state pluripotent stem cells (Gafni et al.).
• Promotes proliferation of human endothelial progenitor cells (Seeger et al.).
• Promotes proliferation of neonatal and adult rat cardiomyocytes (Engel et al.).

DIFFERENTIATION

• Enhances differentiation of cardiomyocytes from human ES cells (Gaur et al., Graichen et al.).
• Inhibits differentiation of cardiomyocytes from mouse ES cells by inhibition of early mesoderm (Davidson and Morange).