SPR Microscope
Optimized SPR instrument for membrane protein and small molecule binding
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A new way to look at kinetics of binding to cell surface targets
kinetics analysis of large and small molecules to cell membrane targets
We have been using the SPRm 200 instrument in our lab for several years now. The combination of microscopy and SPR are an enticing feature of the technology allowing us to perform kinetic binding studies of large and small molecules to targets on cells. This had been very helpful in our efforts. unlike a traditional biosensor which use primarily recombinant protein, here you are working with cells. Having access to those with cell culture knowledge is helpful in this respect. Once completed though you can then inject your analytes over the cells and investigate the binding response. This instrument has a lot to offer in this area of drug development.
Review Date: 15 Dec 2022 | Biosensing Instrument
The Surface Plasmon Resonance Microscopy (SPRM) system, integrates optical microscopy and SPR. It is a powerful technique for measuring the binding activities of membrane proteins in vitro. It allows the simultaneous measurement of phenotypical changes of the sample via bright field and binding strength and kinetics via SPR.
Integrated optical microscopy with SPR Bright-field and SPR microscopies in one instrument. Large field of view with high-resolution optics to view single or multiple cells.
In vitro and label-free binding activities, mapping Provides SPR sensorgrams and binding activity maps of individual cells as well as the binding kinetic constants (ka, kd, KD).
Nanometer scaled binding response of virus, bacteria, and nanoparticles Nanomotion detection study of bacteria or virus metabolic activity or binding activities of nanoparticles for drug delivery designs.
