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Target Deconvolution with CETSA

Target Deconvolution service based on proteome-wide Cellular Thermal Shift Assay using Mass Spectrometry detection is performed in intact cells and lysate without any compound modifications.

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Pelago Bioscience

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Target deconvolution is a crucial step in drug discovery, as it reveals drug candidate’s interactions with intended and unintended targets. However, traditional methods for target identification are often time-consuming, labor-intensive, and prone to false positives. To overcome these challenges, we offer a service based on the cellular thermal shift assay (CETSA), that measures the thermal stability of proteins in response to compound binding completely label free.
Our service combines the advantages of CETSA with the power of mass spectrometry (MS) to provide comprehensive and reliable target deconvolution results. By subjecting your compound of interest to our target deconvolution service, we can help you identify both direct and indirect protein targets. Our service can be performed on various biological samples, including intact cells, cell lysates, and tissues.
With our CETSA-based target deconvolution service, you can benefit from:

  • Fast and robust target deconvolution not requiring modification of your compound and target proteins.
  • A comprehensive and unbiased proteome-wide analysis covering over 7,000 proteins and for identification of both on-target and off-target interactions.
  • Target Identification in biologically relevant cell system
  • Our target deconvolution service can be applied to various aspects of drug discovery research, such as:
  • Target identification as follow-up from a phenotypic screen
  • Mechanism of action studies

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