Tbx21 (T-beta) Knockout Rat
T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN γ. Due to a hypersensitive immune system, the Tbx21 (-/-) rat model is useful for studies of acute and chronic human asthma, Crohn’s disease, colitis, cancer metastasis, autoimmune disorders and inflammation.Tbx21 (T-beta) Knock…
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T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN γ.
Due to a hypersensitive immune system, the Tbx21 (-/-) rat model is useful for studies of acute and chronic human asthma, Crohn’s disease, colitis, cancer metastasis, autoimmune disorders and inflammation.
Tbx21 (T-beta) Knockout Rat Characteristics:
- Macrophages from homozygous knockout rats demonstrate less Th1 response with less IFN-γ secretion after simulation with PMA
- Homozygous knockout rats show decreased bone mass
- Homozygous knockout rats show elevated serum alkaline phosphotase levels
- Background Strain: Sprague-Dawley
Research Applications:
- Rheumatoid arthritis
- Inflammation/Autoimmune disorders
- Asthma
- Multiple sclerosis
- Thrombosis/Cardiac fibrosis
- Vascular defects
- Platelet defects/Platelet aggregation
- Renal dysplasia
- Crohn's disease
- Colitis
