Products & ReviewLife Sciences
Trichostatin A
Epigenetic modifier; Inhibits histone deacetylase (HDAC)1 and HDAC6
Trichostatin A
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Trichostatin A is a potent and reversible inhibitor of Histone Deacetylase (HDAC), therefore acting as an epigenetic modifier by preventing the removal of acetyl groups from lysine residues on histone tails. Trichostatin A inhibits both class I and class II HDACs, including HDAC1 (IC₅₀ = 6 nM), HDAC4 (IC₅₀ = 38 nM), and HDAC6 (IC₅₀ = 8.6 nM). (Furumai et al.; Yoshida et al.)
REPROGRAMMING
- Increases the reprogramming efficiency of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells (Huangfu et al.).
- Resets epigenetic memory in mouse iPS cells, in combination with 5-Azacytidine (Kim et al.).
- Increases the efficiency of cloned mouse embryo development by somatic cell nuclear transfer (Kishigami et al.).
MAINTENANCE AND SELF-RENEWAL
- Prevents dedifferentiation of primary rat hepatocytes in culture, maintaining liver-specific cellular functions (Henkens et al.).
DIFFERENTIATION
- Promotes differentiation of hepatocytes from human mesenchymal stem cells (Snykers et al.).
