Twist Alliance CeGaT RNA Fusion Panel Kit
The Twist Alliance CeGaT RNA Fusion Panel is a targeted RNA sequencing solution designed to detect both known and novel gene fusions across 160 genes associated with over 30 cancer types, enhancing cancer and precision medicine research.
Receive your quote directly from the manufacturer.
Gene fusions, resulting from chromosomal rearrangements, are significant drivers in various cancers and serve as critical biomarkers for disease identification and monitoring. The Twist Alliance CeGaT RNA Fusion Panel combines Twist Bioscience's high-quality RNA library preparation and target enrichment capabilities with CeGaT's expertise in tumor diagnostics and panel design. This collaboration has produced a comprehensive panel that captures fusion transcripts involving 160 genes linked to over 30 cancer types. The panel's design allows for the detection of both expected and novel fusion events, providing a robust tool for researchers aiming to uncover complex genomic alterations. By enriching for fusion transcripts, the panel increases the sensitivity of fusion detection, even in samples where the fusion partners or breakpoints are unknown. This targeted approach reduces sequencing costs and data analysis complexity compared to whole transcriptome sequencing. The panel has demonstrated high sensitivity in detecting known fusion variants and has been validated across various sample types, including formalin-fixed paraffin-embedded (FFPE) tissues.
Key features:
- Comprehensive Coverage: Targets 160 genes associated with over 30 cancer types, enabling the detection of a wide range of fusion events.
- Detection of Novel Fusions: Capable of identifying unexpected fusion breakpoints and novel coding variants within the targeted genes.
- High Sensitivity: Demonstrated high sensitivity in detecting known fusion variants in validation studies.
- Optimized Workflow: Integrates seamlessly with Twist's RNA Library Prep Kit, providing a streamlined process from library preparation to sequencing-ready libraries.
Applications:
- Oncology Research: Facilitates the identification of gene fusions that drive cancer development, aiding in the understanding of tumor biology.
- Biomarker Discovery: Assists in uncovering fusion events that can serve as biomarkers for cancer subtyping and monitoring minimal residual disease.
- Precision Medicine: Supports the development of targeted therapies by identifying actionable gene fusions in various cancer types.
For research use only. Not for use in diagnostic procedures.
