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Twist cfDNA Pan-cancer Reference Standards

Twist's cfDNA Pan-Cancer Reference Standard v2 provides researchers with high-quality, synthetic reference materials to assess and validate liquid biopsy assays, enhancing the detection of low-frequency cancer associated variants.

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The cfDNA Pan-Cancer Reference Standard v2 from Twist Bioscience is engineered to support the development and validation of liquid biopsy assays by offering a reliable source of synthetic cell-free DNA (cfDNA). This standard comprises a mixture of wild-type and mutant cfDNA fragments, mimicking the fragmented nature of cfDNA found in human plasma. It includes a diverse set of cancer-relevant variants across multiple genes, enabling comprehensive performance assessment of assays targeting various mutations. The reference standard is available in multiple variant allele frequencies (VAFs), allowing researchers to evaluate the sensitivity and specificity of their assays in detecting low-frequency mutations. By providing a consistent and well-characterized material, Twist's cfDNA Pan-Cancer Reference Standard v2 aids in establishing the analytical limit of detection and serves as a control to monitor assay performance over time.

Key features:

  • Comprehensive Variant Coverage: Contains a broad spectrum of cancer-related mutations across multiple genes, reflecting the heterogeneity of tumor genetics.
  • Fragmented cfDNA Mimicry: Replicates the size distribution of cfDNA found in human plasma, ensuring realistic assay evaluation.
  • Multiple VAF Options: Available in various allele frequencies, including low-frequency variants, to assess assay sensitivity.
  • High-Quality Synthetic Material: Provides a consistent and well-characterized reference standard reducing sample variability.

Applications:

  • Liquid Biopsy Assay Development: Serves as a benchmark for developing and optimizing assays aimed at detecting cfDNA mutations in plasma samples.
  • Analytical Validation: Assists in determining the limit of detection, linearity, and precision of cfDNA-based assays.
  • Quality Control: Acts as a positive control to monitor the ongoing performance and reliability of diagnostic assays.

For research use only. Not for use in diagnostic procedures.

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