Twist RNA Exome
The Twist RNA Exome offers a comprehensive solution for capturing human protein-coding regions, enabling efficient transcriptome analysis, isoform study, and fusion detection with high sensitivity and specificity.
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The Twist RNA Exome is designed to enrich for human protein-coding exons, providing a cost-effective approach for comprehensive transcriptome analysis. Utilizing an exon-aware design strategy, it targets known protein-coding isoforms and enables the discovery of novel fusion genes. This design ensures uniform coverage across targeted regions, facilitating accurate gene expression profiling and isoform detection. The panel covers 19,708 genes and 63,215 isoforms, offering extensive insight into the transcriptome. Its high sensitivity allows for the detection of low-expressing targets, even in degraded RNA samples such as those from formalin-fixed paraffin-embedded (FFPE) tissues. By increasing the signal and requiring fewer sequencing reads, the Twist RNA Exome enables researchers to allocate resources efficiently, analyzing more samples or detecting more targets within existing samples.
Key features:
- Exon-Aware Design: Targets protein-coding regions and unique splice sites, facilitating comprehensive transcriptome analysis and fusion detection.
- Extensive Coverage: Encompasses 19,708 genes and 63,215 isoforms, providing a broad view of the transcriptome.
- High Sensitivity: Detects low-expressing targets, even in degraded RNA samples like FFPE tissues, ensuring accurate gene expression profiling.
- Efficient Sequencing: Increases signal while requiring fewer sequencing reads, allowing for the analysis of more samples or the detection of more targets within existing samples.
Applications:
- Gene Expression Analysis: Quantify RNA transcripts to study gene expression patterns across various conditions or treatments.
- Isoform Detection: Identify and study different splice variants of genes, enhancing understanding of gene regulation and function.
- Fusion Gene Detection: Detect known and novel gene fusions, which are critical in various cancers and genetic disorders.
- Transcriptome Profiling: Perform comprehensive analysis of the transcriptome to uncover novel transcripts and gain insights into gene function.
For research use only. Not for use in diagnostic procedures.
