Tyrosine Hydroxylase (TH)-Cre Rat
This model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lin…
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This model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons.
This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines.
Tyrosine Hydroxylase (TH)-Cre Rat Characteristics:
- Cre recombinase driven by endogenous TH promoter
- No observed ectopic expression of cre
- Targeted insertion eliminates possible gene disruption that may occur in random insertion technologies such as BAC
- Background Strain: Sprague-Dawley
Research Applications:
- Optogenetics
- DREADD
- Expression/knockout of floxed genes
