GL Sciences, Inc. Products & Reviews

Inertsil ODS columns are general-purpose reversed phase C18 columns, available in 5-µm and 10-µm particle sizes. It was the first of the ODS columns from GL Sciences, introduced back in 1986. We currently recommend InertSustain C18 or Inertsil ODS-4 columns for all new method developments.

Silica-based columns are stable and efficient but unsuitable for alkaline analyses due to the silica matrix's weakness under high pH. InertSustain C18, with its novel surface-modified silica, overcomes this limitation. It retains Inertsil's benefits—low back pressure, superior inertness, high efficiency, consistent performance, and wide solvent compatibility—while enabling analyses over a broad pH range.

EPA Method 1633 efficiently determines PFAS in complex samples. InertSep, a line of solid-phase extraction cartridges, is known for high purity, consistency, and quality. InertSep WAX FF and GCB offer high recovery rates and cleanup efficiencies for PFAS in water, soil, food, and other complex matrices. InertSep GCB, packed with Graphite Carbon Black, is ideal for LC/MS analysis due to its excellent cleanup efficiency.

InertSep QuEChERS Kit is a product developed by leveraging decades of expertise in manufacturing high-quality chromatography products. This kit efficiently removes impurities such as organic acids, sugars, fatty acids, pigments, chlorophyll, and carotenoids from samples, enhancing the accuracy and reliability of subsequent analyses using LC/MS or GC/MS.

Inertsil Hybrid-C18 is a high-pH resistant HPLC column that enables stable and reproducible separations across a wide pH range (1–12). Built with hybrid silica technology, it ensures excellent peak shapes even for basic analytes and provides superior lifetime compared to conventional C18 columns. Available in 1.7 µm, 3.5 µm, and 5 µm, it is ideal for LC-MS and method development.

GL Sciences' Bio LC Columns "ProteoSil" are tailored HPLC solutions designed specifically for proteomics and the analysis of bio molecules such as proteins, peptides, and nucleic acids. The packing materials used in these columns are crafted from high-purity silica, offering pore sizes of 100Å, 200Å, and 300Å. They are available in multiple configurations, including reversed phase, HILIC, and size exclusion columns.

InertSep Oligo is a solid-phase extraction (SPE) product for oligonucleotide purification in LC/MS workflows. It delivers high recovery, low variability, and full LC/MS compatibility. Formats include 96-well plates—Micro Elution (2 mg/400 µL) and 2 mL square-well (25 mg)—and straight barrel cartridges in multiple sizes for manual or automated high-throughput sample prep.