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ChemiSCREEN™ Membrane Preparation Recombinant Human CXCR7 Chemokine Receptor

Merck

Chemicon's CXCR7 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of agonists and antagonists at CXCR7. The membrane preparations exhibit a Kd of 0.32 nM for [125I]-SDF-1α. With 0.25 nM [125I]-SDF-1α, 10µg/well CXCR7 Membrane Prep typically yields greater than 4-fold signal-…

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ChemiScreen™ Membrane Preparation Recombinant Human EP4 Prostanoid Receptor

Merck

Chemicon's EP4 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of EP4 interactions with prostaglandin E2. The membrane preparations exhibit a Kd of 1.27-1.85 nM for [3H]-Prostaglandin E2. With 5 µg/well EP4 Membrane Prep and 1.5 nM [3H]-Prostaglandin E2, a gr…

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ChemiSCREEN™ Human Recombinant mGlu1 Metabotropic Glutamate Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon’s cloned human mGlu1-expressing cell line is made in the Chem-3 host, which supports high levels of recombinant mGlu1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for functional screening agonists, antagonists and modulators of mGlu1.

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ChemiSCREEN™ Human Recombinant mGlu2 Metabotropic Glutamate Receptor Calcium-Optimized Stable Cell Line

Merck

EMD Millipore’s cloned human mGlu2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant mGlu2 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and allosteric modulators of mGlu2.

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ChemiSCREEN™ Membrane Preparation Recombinant Human mGLU2 Metabotropic Glutamate Receptor

Merck

Chemicon's mGlu2 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of mGlu2 interactions with its ligands. The cell line exhibits a calcium response with EC50s of 0.51uM, 5.6uM, and 8.3uM for DCG IV, (2R4R) APDC, and glutamate. The membrane preparations exhibit EC50s of of 0.…

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ChemiSCREEN™ Human Recombinant GLP-1 Glucagon-Like Peptide Receptor Calcium-Optimized Stable Cell Line

Merck

EMD Millipore's cloned human GLP-1 -expressing cell line is made in the Chem-9 host, which supports high levels of recombinant GLP-1 expression on the cell surface and contains high levels of promiscuous G proteins to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between GLP-1 and its ligands.

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ChemiSCREEN™ Human Recombinant GLP-1 Glucagon-Like Peptide Receptor cAMP/Calcium-Optimized Stable Cell Line

Merck

EMD Millipore’s cloned human GLP-1 Receptor -expressing cell line is made in the CHO host, which supports optimal levels of recombinant GLP-1 Receptor expression for robust agonist-induced cAMP signal. In addition, the cell line contains optimized levels of a proprietary promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists…

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ChemiScreen™ Calcium-Optimized Stable Cell Line Human Recombinant SST3 Somatostatin Receptor

Merck

Chemicon's cloned human SST3-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant SST3 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between the SST3 and its ligands.

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ChemiScreen™ Calcium-Optimized Stable Cell Line Human Recombinant CGRP1 Calcitonin Receptor-Like Receptor

Merck

Chemicon's cloned human CGRP1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CGRP1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CGRP1 and its ligands.

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ChemiSCREEN™ Human Recombinant S1P1 Lysophospholipid Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human S1P1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant S1P1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P1 and its ligands.

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ChemiSCREEN™ Membrane Preparation Recombinant Human S1P1 Lysophospholipid Receptor

Merck

EMD Millipore's S1P1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P1 interaction with its ligands. The cell line exhibits a calcium response with EC50s of 141 μM for Sphingosine 1-phosphate. The membrane preparations exhibit EC50s of 9.5 μM for Sphingosine 1-phospha…

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ChemiSCREEN™ Human Recombinant PK2 Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human PK2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant PK2 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between PK2 and its ligands.

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ChemiSCREEN™ Membrane Preparation Recombinant Human EP2 Prostanoid Receptor

Merck

EMD Millipore's EP2 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of agonists and antagonists of EP2. The membrane preparations exhibit a Kd of 14.52 nM for [3H]-PGE2. With 7.5 nM [3H]-PGE2, 10µg/well EP2 Membrane Prep typically yields greater than 3-fold signal-to-backgr…

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ChemiSCREEN™ Human Recombinant Ghrelin Receptor Calcium-Optimized Stable Cell Line

Merck

EMD Millipore’s cloned human Ghrelin Receptor-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant Ghrelin Receptor expression on the cell surface and contains high levels of the promiscuous G protein to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at Ghrelin Receptor.

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ChemiSCREEN™ Membrane Preparation Recombinant Human Gherlin Receptor

Merck

EMD Millipore's Ghrelin Receptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of ghrelin interactions and its ligands. The membrane preparations exhibit a Kd of 0.32 nM for [125I]-ghrelin. With 0.1 nM [125I]-ghrelin, 5 μg/well Ghrelin Receptor Membrane Pre…

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ChemiSCREEN™ Human Recombinant S1P5 Lysophospholipid Receptor Calcium-Optimized Stable Cell Line

Merck

EMD Millipore's cloned human S1P5-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P5 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P5 and its ligands.

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ChemiSCREEN™ Chem-1 Parental Cell Line

Merck

Chemicon's Wild-Type Chem-1 cell line is a control for Chemicon's GPCR-expressing Chem-1 calcium-optimized cell lines. The Chem-1 cell line is adherent to tissue culture-treated surfaces and contains high levels of the promiscuous G protein Galpha15 to couple many classes of GPCRs to the calcium signaling pathway.

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Direct Detect® Spectrometer

Merck

Introducing Direct Detect™, the first infrared (IR)-based biomolecular quantitation system. Just spot your sample, blank, and read! No sample prep, standard curves, messy cuvettes or liquid waste. With inherent amide bond detection, the Direct Detect™ system distinguishes proteins and peptides from interfering sample components, providing more accurate results without the pitfalls of colorimetric assays. Technology: FTIR Spe…

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