EMD Millipore’s cloned human Ghrelin Receptor-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant Ghrelin Receptor expression on the cell surface and contains high levels of the promiscuous G protein to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at Ghrelin Receptor.
EMD Millipore's Ghrelin Receptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of ghrelin interactions and its ligands. The membrane preparations exhibit a Kd of 0.32 nM for [125I]-ghrelin. With 0.1 nM [125I]-ghrelin, 5 μg/well Ghrelin Receptor Membrane Pre…
Chemicon's cloned human S1P4-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P4 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P4 and its ligands.
EMD Millipore's cloned human S1P5-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P5 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P5 and its ligands.
EMD Millipore's S1P5 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P5 interactions with its ligands. The membrane preparations exhibit EC50s of 2.4 nM for S1P in a GTPγS binding assay.
EMD Millipore’s cloned human GPR92 -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GPR92 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at GPR92.
EMD Millipore’s cloned human GPR91 -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GPR91 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at GPR91.
Chemicon's Wild-Type Chem-1 cell line is a control for Chemicon's GPCR-expressing Chem-1 calcium-optimized cell lines. The Chem-1 cell line is adherent to tissue culture-treated surfaces and contains high levels of the promiscuous G protein Galpha15 to couple many classes of GPCRs to the calcium signaling pathway.
Indispensable for NMR spectroscopy Unlocking the molecular structure of organic molecules is central to understanding how they interact with other molecules. This is especially critical in genomics, proteomics and drug discovery research. The Nuclear Magnetic Resonance (NMR) technique allows scientists to “see” molecular structure and dynamics. MagniSolv™ deuterated solvents are a key tool for the NMR technique. MagniSolv™ deu…
The ProteoPlex™ 16-Well Human Cytokine Array Kit is designed for multiplex detection and measurement of 12 important human cytokines in parallel from up to 15 experimental samples. The combination of advanced surface chemistry, well-characterized capture agents, and a highly-sensitive fluorescence-based detection system provides a robust method for comparing relative cytokine abundance or cytokine quantification in serum sampl…
Complete range of Calbiochem® high quality detergents including Bile Salts Detergent Adsorbents Detergent Kits Ionic Non-Detergent Sulfobetaines (NDSB) Non-Ionic Zwitterionic
Eshmuno® CPX media - High aggregate removal efficiency combined with high dynamic binding capacity Eshmuno® CPX media is a strong cation exchanger built on the proven Eshmuno® resin technology. Eshmuno® CPX media combines high aggregate removal efficiency in downstream purification linked to an outstanding high dynamic binding capacity, utilizing the 50 μm Eshmuno® base bead technology and EMD Millipore’s proprietary tentacle…
SmartFlare Probes work by recognizing specific native RNA sequences within living cells, therefore there are many possible sequences that you could design to recognize your target of interest. Instead of lysed cells, switch to live cells. And while you’re at it, eliminate sample preparation and transfection steps all together. Live cell RNA detection is now possible, in a single incubation step using inert nanoparticle techno…
Eshmuno® A is a rigid, high capacity Protein A affinity chromatography resin for the purification of Fc-containing proteins, including but not limited to monoclonal antibodies. Eshmuno® A resin can be cleaned and sanitized under acid and alkaline conditions while maintaining high dynamic binding capacity at high flow rates.The Eshmuno® A resin contains a EMD Millipore proprietary ligand. This ligand is recombinantely expresse…
The Watercol capillary GC columns allow the qualitative and quantitative analysis of water in a variety of matrices, by GC, eliminating the need for special testing for water.
Supel ™ Genie Online SPE cartridges are a sample preparation solution that offer a seamless workflow from start to finish performed entirely 'online' the LC instrument. Typically, an autosampler would take the samples from a collection plate or tubes, and inject them directly onto the SPE cartridge located on the analytical instrument (LC instrument). This enables an entirely hands free workflow which eliminates the risk o…
Supel™ Genie HybridSPE® online cartridges have been developed as an alternative to traditional 96-well plate and individual cartridge formats for phospholipid removal and sample preparation. The HybridSPE online cartridges have been designed for online phospholipid removal allowing direct injection of protein precipitated samples for LC/MS analysis. When the samples flow through the HybridSPE online traps, the phospholipids ar…
BIOshell™ HPLC and UHPLC columns deliver maximum speed and efficiency for the separation of biomolecules on both HPLC and UHPLC systems. The novel, superficially porous silica particles (SPP), with pore sizes from 90 Å up to 1000 Å, allow the separation of glycans as well as of very large proteins.
Our HybridSPE ® -PLus plates effectively remove phospholipids and proteins from biological matrices in a simple pass-through method for accurate and reproducible LC-MS analysis. Unlike other phospholipid removal SPE products on the market, the unique retention mechanism of HybridSPE ® allows for separation of even very hydrophobic analytes from phospholipid contaminants.
Supel™ Swift HLB is a polymeric stationary phase for solid phase extraction (SPE) prior to instrumental analysis. It has both hydrophilic and lipophilic functional groups for the extraction of a broad range of compounds from aqueous samples. It retains analytes having diff erent polarities and Log P values due to its hydrophilic and lipophilic balance (HLB) property.
Supel™ BioSPME 96-Pin Devices were developed to greatly improve upon the speed and simplicity plasma protein binding studies and other free analyte analyses. Our technology offers a 3x faster workflow compared to rapid equilibrium dialysis based methods, is amenable to both automation and manual operation, and is a convenient universal 96-pin format compatible with standard 96-well consumables.
