Supel ™ Genie Online SPE cartridges are a sample preparation solution that offer a seamless workflow from start to finish performed entirely 'online' the LC instrument. Typically, an autosampler would take the samples from a collection plate or tubes, and inject them directly onto the SPE cartridge located on the analytical instrument (LC instrument). This enables an entirely hands free workflow which eliminates the risk o…
Supel™ Genie HybridSPE® online cartridges have been developed as an alternative to traditional 96-well plate and individual cartridge formats for phospholipid removal and sample preparation. The HybridSPE online cartridges have been designed for online phospholipid removal allowing direct injection of protein precipitated samples for LC/MS analysis. When the samples flow through the HybridSPE online traps, the phospholipids ar…
lyophilized powder, Fatty acid free, Globulin free, =99% (agarose gel electrophoresis)
Fetal Bovine Serum (FBS) is the most widely-used growth supplement for cell culture, containing a complex mixture of biomolecules that includes growth factors, proteins, trace elements, vitamins and hormones for cell growth. Our extensive portfolio of FBS enables you to easily select the right FBS for your culture and criteria.
Highly characterized, cryopreserved human colon intestinal organoids derived from integration-free human induced pluripotent stem cells (iPSCs).
The 3dGRO™ Human Lung Organoid Culture System is a multi-stage culture system for efficient differentiation of human induced pluripotent stem (iPS) cells to mature lung organoids.
Decellularized extracellular matrix (dECM) hydrogels for 2D and 3D cell culture applications.
Ready-to-use, 96-well black-walled glass-bottom microplates containing precast synthetic hydrogels designed to easily establish 3D cell cultures by direct seeding of cells.
Validated, ethically-sourced human primary and stem cells from industry-leading manufacturer PromoCell ® .
Sigma-Aldrich ® one-part sgRNA and two-part crRNA:tracrRNA systems accelerate genome editing with Cas9 protein, mRNA, or established Cas9 expressing cell lines. Our guides are compatible with a variety of delivery methods including microinjection, electroporation, and lipofection.
With the largest portfolio of Cas9 proteins available, Merck make it easy to find the perfect nuclease for your gene editing experiment.
Merck's immuno-oncology cell lines are innovative research tools for biologics discovery and clinical development. These are the perfect cell-based assay tools you need for the entire drug discovery and clinical development process. Whether you need screening tools for CAR/TCR therapies and mAB development, target cells for efficacy testing, or potency assays for clinical development, Merck provides functional biologically-re…
The largest and most validated shRNA collection from the RNAi consortium (TRC). Merck's unique shRNA formats leverage the discovery potential of the trusted and proven TRC shRNA collection. When you partner with them, you gain access to their world class lentiviral production expertise and the formats and specifications for RNAi knockdown experiments at any scale.
A comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients.
Nuclease-independent applications of CRISPR provide equal targeting specificity but instead of cutting, CRISPRi allows for targeted interference of gene function by delivering transcriptional repressor domains to a specific target sequence using modified dCas9 + gRNA complexes. Gene knockdown is complementary to CRISPR-KO and CRISPRa (activation) and has distinct advantages over existing loss-of-function strategies like RNAi.…
Patient-derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology.
MS β-glucuronidase is a prebuffered, bench-stable, and automation-ready hydrolysis mix for urine drug testing workflows. Discover how to leverage its reduced hands-on time and improved stability.
The T7 Endonuclease Detection Assay is a well-known method for detecting genome editing events from CRISPR, Zinc-finger nuclease, and TALEN gene targeting. Originally identified from Escherichia coli bacteriophage, the T7 endonuclease can cleave mismatched heteroduplex DNA, Holliday junctions, branched DNA, and cruciform DNA.
All-in-one, ready-to-use Cas9 and guide RNA (gRNA) expression plasmids for use with monocots and dicots.
CRISPR/Cas9-mediated recombineering is the most powerful bacterial genome engineering method to date. In addition, Cas9-mediated recombineering overcomes the dependence on a second recombination step, avoids the creation of destabilizing scar sites, can be used in multiplexing, and is less time-consuming than previous protocols.
This Lentiviral Packaging Mix is an optimized formulation of two plasmids expressing the key HIV packaging genes and a heterologous viral envelope gene.
