Drug discovery > Basic Research Products & Reviews

Deep coverage of clinically focused targets that allow for the study of methylation patterns that may be relevant to early cancer detection and diagnosis from tumor and liquid biopsy samples.

Streamline the identification of heritable disease-linked alleles, be it through carrier screening or pre- and post-natal testing.

The Twist Alliance Clinical Research Exome helps support the Broad Institute Genomics Platform and was designed using validated data from clinical patient samples.

The Twist Alliance Canine Exome developed in collaboration with the Broad Institute

The Twist Alliance CNTG Exome - 41 MB provides highly uniform coverage of the entire exome as well as full coverage of the mitochondrial genome.

Coverage of rare disease-associated genes 

Coverage of 72 selected cancer-associated genes

The Twist Respiratory Virus Research Panel enables comprehensive detection and sequencing of 29 common respiratory viruses, allowing researchers to identify pathogens and analyze their genomes.

Fast and Easy Library Workflows

Twist's RNA Sequencing Solutions provide comprehensive next-generation sequencing (NGS) workflows, offering both targeted and whole transcriptome approaches to generate uniform, high-quality RNA sequencing libraries from diverse sample types.

The Twist RNA Exome offers a comprehensive solution for capturing human protein-coding regions, enabling efficient transcriptome analysis, isoform study, and fusion detection with high sensitivity and specificity.

The Twist NGS Methylation Detection System provides a robust, end-to-end sample preparation solution for identifying methylated regions in the human genome. The workflow employs a unique enzymatic process from New England Biolabs® that is much less damaging to DNA, alongside Twist‘s Custom Methylation Panel design.

The Twist Bioscience MRD Rapid 500 Panel is a scalable target enrichment solution for monitoring minimal residual disease that leverages Twist’s silicon based DNA synthesis platform to design and manufacture capture panels for personalized medicine. 

The Twist UMI Adapter System enhances the detection of low-frequency somatic variants in cell-free DNA (cfDNA) by incorporating unique molecular identifiers (UMIs) during library preparation, increasing sensitivity and reducing PCR errors.

Twist's cfDNA Pan-Cancer Reference Standard v2 provides researchers with high-quality, synthetic reference materials to assess and validate liquid biopsy assays, enhancing the detection of low-frequency cancer associated variants.

High Sensitivity. High Conversion. Low-Input

Twist’s RNA sequencing workflows offer a complete NGS solution that produces uniform libraries for RNA sequencing.

COMET™ is a fully automated, high-throughput, hyperplex platform for the analysis of Formalin-Fixed, Paraffin-Embedded (FFPE), and frozen tissues.

Tools to acelerate biomarker identification and validation

The Transcreener dAMP Exonuclease Assay directly measures dAMP produced by exonuclease enzymes as they cleave polynucleotides. 

Express proteins—even large and challenging constructs—and conduct screening studies directly in HEK293 cells using efficient, reliable TARGATT™ large knock-in technology. With the ability to efficiently and site-specifically insert 20+ kb of DNA (more with nested reactions) into the reliable H11 safe harbor site, TARGATT™ HEK293 kits move you to the next inflection point faster.

Express proteins—even large and challenging constructs—and conduct screening studies directly in CHO K1 cells using efficient, reliable TARGATT™ large knock-in technology. With the ability to efficiently and site-specifically insert 20+ kb of DNA (more with nested reactions) into the reliable H11 safe harbor site, TARGATT™ CHO K1 kits move you to the next inflection point faster.

Build tomorrow’s cell therapies and cell-based disease models using TARGATT™ Human Induced Pluripotent Stem Cell (hiPSC) Kits. With the ability to efficiently and site-specifically insert 20+ kb of DNA (more with nested reactions), TARGATT™ hiPSC technology enables expression of large proteins and multi-protein complexes in hiPSC-derived human cell lines.

PurePlus™ Deep Well Plates 96-well plates are designed for automation, high throughput screening (HTS), or heavy lab use. Each well holds either 1.2 mL or 2.2 mL and has smooth inside surfaces to ensure that all of your samples can be pipetted.

Breakthrough stereo microscope optics delivering the world's highest zoom ratio of 25:1, unprecedented resolution and bright, fluorescent images. Capture stunning images and time-lapse data with incredible detail and field of view.