Drug discovery > Basic Research Products & Reviews

Products, services, reviews and techniques used in the preliminary investigations of the disease; the cell biology, genetics and protein pathways using tissue culture, cloning and imaging.

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pET vectors

Merck

The pET System is the most powerful system yet developed for the cloning and expression of recombinant proteins in E. coli. Based on the T7 promoter-driven system, Novagen’s pET System has been used to express thousands of different proteins. pET Vectors are supplied as purified plasmid DNA (10 µg) plus an Induction Control strain (supplied as a glycerol stock). Complete sequences and detailed vector maps are available.

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D-Tube™ Dialyzers

Merck

The D-Tube™ Dialyzers can be used for dialysis and electroelution of proteins or nucleic acids from polyacrylamide or agarose gels. The disposable, single-use tubes require no syringes, microcentrifuges, or laborious steps to manipulate small samples volumes. The sample is added and removed using a standard laboratory pipette. Available with molecular weight cut-offs from 3.5 to 14 kDa, the D-Tube Dialyzers are designed in thr…

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Corning® 96-well Clear Polystyrene High Bind Stripwell™ Strips, without Frame or Lid, Nonsterile

Corning Life Sciences

May be used in a variety of laboratory assays Flat bottom strips are designed to easily break apart and may be used in an style strip holder that allows each individual well to be positioned back into the plate once broken High binding surface binds medium (>10kD) and large biomolecules that possess ionic groups and/or hydrophobic regions. Binding capacity is approximately 400 to 500ng IgG/cm2. Ideal for immunoassays Reco…

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Morphology Explorer V2 Image Analysis BioApplication

Morphology Explorer V2 is a powerful general-purpose image analysis application for measuring size, shape, and distribution of cells, colonies, and subcellular components.  It performs sophisticated calculations in a turn-key, automated manner allowing higher throughput of complex cell-based assays.  This application has been biologically validated, enhancing confidence in your image-based data.    Available for the Cellomics…

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Cell Health Profiling V2 Image Analysis BioApplication for Apoptosis and Cytotoxicity

Cell Health Profiling V2 is a flexible image analysis application employing advanced cell-level logic to detect and classify cell health-related events.  It analyzes patterns of cellular fluorescent labeling that can be used to classify cells as undergoing apoptotic, necrotic, or other cell death mechanisms.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for the Cel…

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Cell Cycle V2 Image Analysis BioApplication

The Cell Cycle V2 BioApplication is a sophisticated image analysis algorithm that performs automated analysis of the cell cycle phase of individual and populations of cells.  It reports cell cycle phase as well as the state of up to 3 target proteins for every cell analyzed, and correlates the target data with DNA content.  This application has been biologically validated, enhancing confidence in your image-based data.  Availa…

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Cytotoxicity V2 Image Analysis BioApplication

The Cytotoxicity V2 BioApplication is an image analysis application that simultaneously measures four markers of cytotoxicity (nuclear fragmentation/condensation, permeability, lysosomal mass-pH, and cell count) and reports individual and composite indicies of cytotoxicity.  The V2 version has been enhanced with object segmentation to allow clumped cells to be efficiently analyzed.  Available for the Cellomics ArrayScan VTI, A…

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Extended Neurite Outgrowth V2 Image Analysis BioApplication for Neurobiology

Extended Neurite Outgrowth V2 is an advanced image analysis algorithm that can quantitate neurite outgrowth with features such as cell body area and branch point quantitation, cell subpopulation analysis, Ability to analyze neuron subsets expressing up to two distinct neurotransmitters.  It reports all features at the cell, well, and subpoulation level, and is biologically validated to enhance confidence in your image-based da…

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Compartmental Analysis V2 Image Analysis BioApplication

Compartmental Analysis V2 is a powerful general image analysis tool for quantitating intracellular intensity changes in specific sub-cellular regions across multiple fluorescent channels.  It performs spot analysis and reports intensity ratios and differences among sub-cellular regions and/or different fluorophores.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for…

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