Drug discovery > Lead Discovery Products & Reviews

In 2004, Waters revolutionized liquid chromatography with the introduction of the ACQUITY UPLC System. At the heart of the system was Waters second generation hybrid, the Ethylene Bridged Hybrid (BEH) particle. In 2005, BEH Technology preparative particle sizes (2.5, 3.5, 5 and 10 μm) with the introduction of XBridge between HPLC and UPLC Technology platforms. BEH Technology particles offer: Excellent peak shape an…

HPLC and UHPLC method compatibility at the flip of a switch.

Extend your LC column lifetime while maintaining chromatographic performance.

Waters Positive Pressure-96 Processor offers state-of-the-art operation for moving liquids through SPE 96-well devices. Each of the 96 holes in the processor manifold is restricted in order to maintain constant pressure, even if all the plate wells positions are not filled. SPE sample processing by positive pressure significantly improves the flow of viscous samples through SPE packed bed by providing highly uniform flow from…

UHPLC columns for unmatched selectivity choice

UV detection, optimized for UPLC/UHPLC separations.

A greener approach to high throughput purification

Improve SPE Reproducibility, Method Transfer, and Processing Efficiency

XBridge® and ACQUITY UPLC® Oligonucleotide C18 Columns for Synthetic Oligonucleotide Analysis and PurificationIon-pair, reversed-phase separation of detritylated oligonucleotides on sub-3 micron particles yields exceptional component resolution.UPLC ® technology increases sample throughput while maintaining necessary oligonucleotide component resolution.LC/UV and LC/MS methods for enhanced quantitative and qualitative oligonuc…

Market Leading LC-TOF-MS with Unrivalled Sensitivity, Exact Mass and Dynamic Range for Qualitative Applications The Waters LCT Premier™ XE is the market-leading orthogonal acceleration time-of-flight (oa-TOF) benchtop mass spectrometer for LC applications. Based on proven and reliable technology, the LCT Premier XE provides unrivalled all round performance for those challenging LC/MS applications. The LCT Premier XE's high sen…

Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) techn…

Excellent low pH stability and high mass loading capability

XBridge Columns include a selection of 10 general-purpose and application-specific sorbents that cover a wide range of particles sizes for analytical and preparative HPLC applications.   XBridge Column users can quickly develop robust methods using mobile phases throughout the entire pH range of 1-12. XBridge OBD™ Preparative Column users, benefit from high pH and temperature stability to provide increased mass loading f…

VanGuard Pre-Columns for UPLC® separations are guard columns that are designed for use with the ACQUITY UPLC® system. These guard columns use an ultra-low volume design (patent pending) that efficiently protects UPLC column performance. This ultra-low volume design does not compromise the UPLC holistic design approach to higher efficiency, greater resolution and increased throughput. Guard columns are typically used in appli…

The Sirocco™ plates are the most technologically advanced protein precipitation plates in the market and enable high-throughput “in-well” protein precipitation of biological samples without the fear of cloudy filtrates or clogged devices. It also provides optimum performance in faster processing time by reducing steps in ‘in-well’ sample processing and complete recovery of clean filtrate from smaller plasma sample volumes.

Designed specifically for polymer characterization, the Styragel® columns are grouped into the HR series for low-to-mid molecular weight samples, the HT series for high-temperature applications, and the HMW series for high molecular weight samples. Specifically controlled styrene divinylbenzene formulations provide reproducible performance in your GPC applications.

Packed with hydroxylated polymethacrylate-based gel, Waters Ultrahydrogel™ SEC columns are ideal for the analysis of aqueous-soluble samples, such as oligomers; oligosaccharides; polysaccharides; and cationic, anionic, and amphoteric polymers. Measuring 7.8 mm x 300 mm, these high-resolution columns offer many advantages over conventional aqueous SEC columns, such as: - A wide pH range (2–12) - Compatibility with high concen…

Sep-Pak Plates enable high throughput solid-phase extraction with the same silica sorbents that have been proven for years in Sep-Pak Cartridges. The plate design has been optimized for automated sample handling systems as well as for standard vacuum manifolds. Sep-Pak Plates are available with different silica sorbent mass selections to optimize sample loading.

The Oasis® uElution plate format combined with the Oasis chemistries allow elution volumes as low as 25uL, eliminating the time consuming evaporation step, producing very clean extracts with a 5 to 10 fold increase in concentration.The Oasis® family of sample extraction products is designed to simplify and improve your sample preparation by combining the right sorbent chemistry, device format and methodology. Achieve robust, s…

The GCT Premier™ benchtop orthogonal acceleration time-of-flight (oa-TOF) mass spectrometer delivers high sensitivity, resolution, and exact mass measurements for GC/MS applications. Its fast data acquisition rates and automated workflow features match the requirements for MS detection when coupled to high-resolution capillary GC. A variety of GC inlet, ion source and software options makes the GCT Premier a versatile choice f…

Acquire, Analyze, Manage, and Share Mass Spectrometry Information MassLynx™ Software increases the speed at which you can convert your sample data into valuable knowledge. It provides you with the fundamental platform to acquire, analyze, manage, and share your mass spectrometry information. MassLynx intelligently controls any Waters mass spectrometry system, from sample and solvent management components to mass spectrometer a…

Waters Xevo™ TQ MS provides the ultimate in quantitative capabilities for your most demanding applications and your most complex sample matrices. It is a highly advanced tandem quadrupole mass spectrometer designed to enable uncomplicated access to superior HPLC and UPLC®/MS/MS performance, delivering the highest levels of sensitivity, selectivity, robustness, speed, and accuracy. Waters Xevo TQ MS is equipped with unique coll…

The AutoSpec Premier™ incorporates Waters’ unique EBE, double-focusing geometry with the extra-wide gap magnet of the proven Ultima NT System. This latest development in magnetic sector technology provides an unmatched combination of high sensitivity, high resolution, and low background noise.The AutoSpec Premier is a powerful platform for high-resolution selected ion recording applications, such as dioxin, polychlorinated bip…

Waters offers scalable prep systems, from the AutoPurification™ System for high-throughput fraction collection from hundreds of samples, to simple low-pressure mixing systems for purifying a few samples a day. Take the complexity out of purification with our versatile solutions that are capable of purifying micrograms to multiple grams, in a single system that can be configured to automatically process hundreds of samples. Key…

The ACQUITY UPLC® Evaporative Light Scattering (ELS) Detector is designed specifically for optimal UPLC®/ELS performance in a small footprint. When your analytes have poor to no UV/Vis response, or don’t ionize well by mass spectrometry, the ACQUITY UPLC ELS Detector with the ACQUITY UPLC System lets you analyze more molecules (including sugars, triglycerides, phospholipids, antibiotics, and natural products) in a single analy…