Identification and optimization of the chemical, series of chemicals or bio-molecule that will interact with the target using impartial, expert opinion about the best equipment, services and the latest techniques
R&D TNF-alpha / TNFSF1A - Recombinant Human Protein Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. Specifications and Use for R&D TNF-alphaSource of R&D TNF• A DNA sequence encoding the mature human TNF-α protein sequence (Accession…
R&D Systems Recombinant Human FGF basic (146 aa) FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35 - 60% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. Specifications and Use of R&D FGF basic Source of R&D FGF • A DNA sequenc…
R&D Systems Recombinant Human IL-6 Interleukin 6 (IL-6) is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic Specifications and Use of R&D IL-6 Source• A DNA sequence encoding the mature human IL-6 protein sequen…
R&D Systems Recombinant Human IGF-I/IGF-1, CF Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Human IGF-I is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides. These isoforms are differentially expressed by various tissues. Specifications and Use of R&D Recombinant Human IGF-1 / ICF-1, CFSource…
R&D Systems Recombinant SCF Protein Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. Specifications and Use for R&D SC…
R&D Mouse TNF-alpha/TNFSF1A DuoSet This R&D DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant mouse Tumor Necrosis Factor alpha (TNF-alpha). DuoSets are designed for the analysis of cell culture supernates. Other sample types, such as serum and plasma, need to be validated prior to use in this R&D DuoSet. Each R&D DuoSet ELISA kit cont…
R&D SCF - Recombinant Mouse Protein Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. Specifications and Use for R&D SC…
R&D Systems Recombinant Human LDL RThe low density lipoprotein receptor (LDLR) is the founding member of the LDLR family of scavenger receptors. This family contains transmembrane molecules that are characterized by the presence of EGF repeats, complement-like repeats, and YWTD motifs that form β-propellers. Specifications and Use for R&D LDL RSource of R&D LDL R• A DNA sequence encoding the signal peptide from human CD33 was…
R&D M-CSF - Recombinant Mouse Protein M-CSF, also known as CSF-1, is the primary regulator of macrophage survival, proliferation and differentiation and is essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis.…
R&D PDGF BB, CF - Recombinant PDGF-BB Human Protein Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the α-granules of platelets activated during the coagulation of blood to form serum. Specifications and Use of R&D PDGFSource of of R&D PDGF • A DNA sequence encoding the 109 amino acid residue mature human PDGF-B chain p…
