Drug discovery > Lead Discovery Products & Reviews

The Common Notification System (CNS) allows the user to monitor an instrument’s status through any networked computer or mobile device with a web browser, thereby increasing walkaway time and process security. The status of the system is immediately visible and the user can easily see if any interaction is needed. Remote monitoring can be particularly useful if the instrument is in a clean room, biosafety cabinet or cold room…

Acclaim™ Trinity P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications such as simultaneous separation of pharmaceutical drug substances and their counterions. his new column, based on nanopolymer silica hybrid (NSH) technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange. As a result, its selectivity can be easily opti…

The Thermo Scientific Acclaim™ Explosives E1 (5 µm) and E2 (5, 3 and 2.2 μm) silica-based reversed-phase columns are designed to resolve all 14 explosives listed in EPA SW-846 Method 8330: Nitroaromatics and Nitramines by HPLC. Their unique chemistries deliver superior resolution with complementary selectivities. The E1 is recommended for use as a direct replacement for ODS columns for the primary analysis.The E2 may be used a…

High-Resolution Separation of Proteins and Peptides The Acclaim® 300 features 3 µm silica particles for rapid analysis of complex protein digests. The Acclaim 300’s stable bonding make these columns compatible with a wide variety of applications, including LC/MS methods.Manufacture of these columns starts with ultrapure silica that contains minimal concentrations of metal contaminants, minimizing the tailing effects of residua…

The DNASwift™ SAX-1S is a strong anion-exchange column that provides exceptionally high resolution for the purification of oligonucleotides.The exceptionally high resolution provides superior purity and yields compared to other ion-exchange or reversed-phase columns available. The DNASwift column is ideal for therapeutic and diagnostic research, which have very high purity and yield oligonucleotides purification requirements.T…

The Thermo Scientific Acclaim™ PepMap™ 100 C18 column sets the benchmark in peptide separation.The PepMap100 C18 column is available in 3 or 5 µm particle sizes, with 100 Å pore sizes, and in nano, capillary, and micro formats. nanoViper fingertight fittings allow for easy column installation.Column Details: Chemistry: C18 Particle Size: 3, 5 μm Pore Size: 100 Å Length: 5, 15, 25, 50 mm ID: 75, 300 μm, 1.0 mm

Acclaim™ PepMap300 C18 is used for the separation of larger peptides and proteins.It is available in 5 µm particle sizes, with 300 Å pore sizes, and in nano, capillary, and micro formats.Column Details: Chemistry: C18 Particle Size: 3, 5 μm Pore Size: 100, 300 Å Length: 5, 15 mm ID: 75, 300 μm, 1 mm

MAbPac™ SCX-10 Columns for the High-Resolution Separation and Analysis of Monoclonal Antibody VariantsThe Thermo Scientific™ MAbPac™ SCX-10 column line has been expanded to include 3 and 5 μm particle sizes for fast, high-resolution analysis as well as rapid separation (RS) columns for bio-UHPLC separations. These smaller-particle-size columns provide the same high resolution as the 10 μm columns, but with…

High-Resolution, Strong and Weak Anion-Exchange Columns for the Separation of ProteinsThe ProPac® SAX-10 is a nonporous, strong anion-exchange column (quaternary amine functional group). The ProPac WAX-10 column is a weak anion exchanger (tertiary amine functional group). Both are based on a nonporous core particle that provides pressure stability. A hydrophilic layer prevents unwanted secondary interactions and a grafted anio…

Strong and Weak Cation-Exchange Columns for High-Resolution Separation of Proteins and MAbsThe Thermo Scientific ProPac™ SCX column line has expanded to include the next generation ProPac SCX-20 column. This column provides unequalled high resolution of protein variants.ProPac SCX-10 and WCX-10 strong and weak cation-exchange columns are based on a nonporous core particle that results in high-efficiency peaks and high-resoluti…

For Hydrophilic Anionic Protein SeparationsThe ProPac® PA1 column supports the analysis and purification of hydrophilic anionic proteins and peptides. Proteins and peptides that are highly cationic (e.g., those with very high isoelectric points) may be resolved on this column, but some may exhibit substantial binding to the column.ProPac® PA1 Protein and Peptide Column Features: Good for hydrophilic anionic proteins and pepti…

Hydrophobic Interaction Chromatography Columns for the Separation of Large BiomoleculesHydrophobic Interaction Chromatography separates biomolecules in a decreasing salt gradient, based on differences in surface hydrophobicity. This method preserves the biological activity of proteins. The HIC separation mechanism is complementary to those of ion-exchange and gel filtration chromatography.The ProPac® HIC-10 column is a high-re…

ProSwift™ ConA-1S Affinity Column for Glycan, Glycopeptide and Glycoprotein Enrichment and Purification The ProSwift ConA-1S affinity monolith column is unsurpassed for fast, highly efficient enrichment and purification of Concanavalin A (Con A) binding glycans, glycopeptides, and glycoproteins from complex samples.The HPLC- compatible ProSwift ConA-1S affinity column maintains the specificity and selectivi…

Monolith Reversed-Phase Columns for High-Resolution Protein Separations at High Flow Rates ProSwift® reversed-phase monolith columns uniquely provide the advantages of high resolution at exceptionally high flow rates for protein separations. They deliver the outstanding resolving power of nonporous analytical media combined with faster separations than any bead based columns available. ProSwift polymer monolith columns achieve…

Monolith Ion-Exchange Columns for Superior High-Resolution Analytical and Preparative Protein Separations The ProSwift SCX monolith column line has been expanded to include a new 1 x 50 mm column. As with all ProSwift monoliths, the fast mass transfer allows for fast protein separations. ProSwift monoliths offer excellent separations using fast gradients at low and high flow rates, which improve productivity.ProSwift Monolith…

The Acclaim™ C30 is designed to provide high shape selectivity for separation of hydrophobic structurally related isomers and unique selectivity complementary to other reversed-phase columns. Acclaim C30 columns are available in 3 and 5μm particle sizes and 4.6, 3.0, and 2.1 mm diameters, with an average pore diameter of 200 Å. It is based on covalent modification of C30 alkyl silane on high-purity, spherical, poro…

The Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one co…

Remove variability and optimize high throughput laboratory workflows. Thermo Scientific™ SOLAµ™Solid Phase Extraction (SPE) Well Plates are designed for bioanalytical and clinical research analysts who require cleaner, highly reproducible, and robust sample extraction using very low sample and solvent volumes in high throughput workflows. SOLAµ Well Plates achieve this due to the unique and award winning innovative frit-less S…

Use Thermo Scientific™ GlycanPac™ AXH-1 LC Columns for qualitative, quantitative, and structural characterization of uncharged and charged glycans present in biological molecules.This high-performance, silica-based high-performance liquid chromatography (HPLC) column provides simultaneous separation of glycans by charge, size and polarity. Achieve high-resolution and high-throughput analysis with unique selectivity for biologi…

Achieve exceptional peak shape and resolution for your HPLC and LC/MS applications with Thermo Scientific™ Hypersil GOLD™ HPLC columns. These endcapped, ultrapure, silica-based columns deliver significant reduction in peak tailing using generic gradients with C18 selectivity. With their excellent resolution, efficiency, and sensitivity, Hypersil GOLD columns give you confidence in the accuracy and quality of your analytical da…

For very hydrophobic analytes, achieve faster separations with excellent peak shapes using Thermo Scientific™ Hypersil GOLD™ C4 HPLC columns. Featuring a lower hydrophobicity than C18 or C8 columns, Hypersil GOLD C4 columns provide outstanding sensitivity and high efficiency.

QuEChERS Dispersive SPE methods offer a convenient and effective approach for extraction and clean-

Improve data quality, lower costs, and increase LC/MS throughput without compromising data quality or sensitivity. The Thermo Scientific™ Transcend™ II system combines proprietary Thermo Scientific™ TurboFlow™ online sample preparation technology and a unique HPLC multi-channel technique to bring the productivity of up to four separate, parallel UHPLC channels to a single mass spectrometer.

Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) systems. Both novices and experts alike can quickly master MS to gain more insights from every sample.

Open new frontiers in isotope ratio mass spectrometry (IRMS) with the Thermo Scientific™ LC IsoLink™ IRMS System.