Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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Supelco® Smart SPME Fibers

Merck

Our Smart SPME fibers are equipped with a unique Smart chip that offers traceability, ease-of-use, and increased productivity. The smart SPME fibers are an extension of our expertise and innovation from traditional SPME coatings to smart SPME format for accurate, reliable, and consistent results.

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Supelco® Overcoated (OC) SPME Fibers

Merck

The over coating of fibers is a new technology in fiber coating to protect the SPME fiber from matrix components. This allows for immersion of the fiber directly into complex samples ensuring a more efficient extraction (e.g. of semivolatile compounds). Polydimethylsiloxane (PDMS) is used to overcoat a PDMS/divinylbenzene (DVB) fiber. The resulting fiber is more physically robust and resistant to chemical fouling and allows f…

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Supelco® Nitinol Core SPME Fibers

Merck

The nitinol-core of SPME fibers enhances the fiber performance and the precision of chromatographic results to enhance lot-to-lot and fiber-to-fiber reproducibility, increase fiber durability, and maintain selectivity and inertness compared to fused silica core fibers.

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Model 2500RTD Water Bath Dissolution Instrument

Distek, Inc.

The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Patented wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel.   

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Model 2500 Select Bathless Dissolution Instrument

Distek, Inc.

The Distek Model 2500 Select Bathless Dissolution System is the culmination of three generations of patented bathless technology with extremely short media heating times and dramatically smaller energy use. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders makes the Model 2500 Select robust and reliable enough for QC applications yet flexible enough…

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Small Volume Dissolution Testing

Distek, Inc.

Performing dissolution tests on high potency drugs with low concentrations of active pharmaceutical ingredients is difficult, if not impossible, with a standard apparatus 1 or 2 dissolution bath. Common analytical instruments are not sensitive enough to detect such low concentrations. Distek's Small Volume Conversion Kit offers the perfect solution to these common dilemmas.  

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Eclipse 5300 Automated Dissolution Sampler

Distek, Inc.

The Distek Eclipse 5300 Automated Dissolution Sampler offers rapid, accurate sampling using precision syringe pumps. The elimination of valves and rotary pumps along with the optimized sample pathway increases reliability while reducing common sources of sample carryover.

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ezfill+ Dissolution Media Preparation

Distek, Inc.

Many of the main causes of OOS dissolution tests and qualification failures are related to media deaeration and dispensing. The unique compact design and optional mobile cart lets one easily move the unit from bath to bath, while the available remote dispensing nozzle allows directly filling vessels in place. The ezfill+ is compatible with most dissolution baths on the market.  

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sensIR 3200 Bathless Disintegration Tester

Distek, Inc.

The Distek sensIR 3200 combines two exclusive technologies – bathless heating and Near IR sensing to offer the most innovative disintegration tester. Bathless heating not only reduces warm-up times but eliminates the inconveniences associated with conventional water bath-based instruments. The sensIR 3200 is available in two, four or six positions in the smallest footprint of any comparably equipped model.  

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Cipher Dissolution Instrument Control Software

Distek, Inc.

The Cipher dissolution control software is a Windows-based application designed and developed by Distek which can be installed locally or networked providing full access to any Distek dissolution instrument on the network. Cipher offers the flexibility to set the level of security appropriate for your laboratory and will meet 21 CFR part 11 compliance.   

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microPro Series Dual Nest

Avidien Technologies

Are you looking for additional labware positions and pipetting flexibility? The Avidien Dual Nest can be easily installed on a new or existing microPro to create a third labware position in a compact 96-channel semi-automated benchtop solution.  

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microPro 20

Avidien Technologies

The world's smallest 96/384 channel semi-automated benchtop pipettor. This innovative compact instrument packs an enormous feature set that offers unprecedented capability and value. It is accurate, affordable, efficient, reliable and easy to use.

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Caco-2 Cells

Merck

Enable assessment of drug transport by comparison between the wild-type (WT) and knockout cell lines

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Automated sample transfer processing system MRA-CDS-102

MEGAROBO Technologies

MegaRobo, as the premier global provider of laboratory automation solutions, independently developed its sample reformatter and has received continuous praises from customers. The system integrates artificial intelligence and automated control for flexibility and for user-friendliness. The MRA-CDS-102 model can easily fit into biosafety cabinets with convenient installation.   

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Automated sample transfer processing system MRA-CDS-610

MEGAROBO Technologies

Megarobo, as the premier provider of laboratory automation solutions in China. CDS-610 sample reformatter, as one of the highest throughput of a single device on the market, integrates steps requiring extensive manual operation into a closed negative pressure system, to achieve a fully automated sample preparation "tube in and plate out".   

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High Throughput Reagent Filling System MRA-LSF-850

MEGAROBO Technologies

Efficient: Up to 8000-10000 pcs/h Flexible: Compatible with multiple types of tubes such as disposable virus sampling tubes Intuitive: Visualization software & touch screen Modular: Including laminar flow, labeling and coding, and CCD modules, allows for personalization Stable: Stable operation, high yield rate Effortless: Only 1 -2 people are needed to complete the whole process

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High Throughput Reagent Filling System MRA-LSF-860

MEGAROBO Technologies

Efficient: Up to 8000-10000 pcs/h Flexible: Compatible with multiple types of tubes such as disposable virus sampling tubes Intuitive: Visualization software & touch screen Modular: Including laminar flow, labeling and coding, and CCD modules, allows for personalization Stable: Stable operation, high yield rate Effortless: Only 1 -2 people are needed to complete the whole process

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CYRIS flox

INCYTON GmbH

CYRIS monitors and analyzes several key cellular parameters in real-time and label-free. Cell viability, metabolism, and morphology can be screened in a fully automated and atmosphere-controlled environment. The incubator integrated solution measures oxygen, pH, and cellular impedance in a multiwell plate and makes through a digital inverse microscope phase-contrast like live-cell images.

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