Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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LH96 Automated Homogenizer Workstation

OMNI International Inc.

The LH96 can be configured to combine multiple sample prep steps into one versatile, efficient and automated device. Quite literally, what used to take hours or days can now be completed in a matter of minutes, and without attendance. The LH96 integrates a core homogenizing platform, capable of efficiently processing a wide variety of samples from 5mL to 50mL tubes, with fully customizable liquid handling capabilities. Patent…

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DPX New mounting medium - water-free, less hazardous

Merck KGaA, Darmstadt, Germany

DPX new – without teratogenic DBP plasticizer for use in histology processes with xylene. In histology, users are in frequent contact with hazardous reagents. During fixation, histoprocessing, staining and mounting, laboratory technicians and pathologists are surrounded by solvents and solvent-containing solutions. These can cause health problems, as they may, for example, be carcinogenic or teratogenic. Di-N-Butyl Ph…

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DYMENSION 1

Syngene

Revolutionary 2DGE Software Analysis of single 2D gels - Dymension 1 is ideal for users looking for software to analyse spots between samples containing one 2D gel only. It offers a range of automatic image correction features and methods for resolving and analysing spots on single gels. The software can be easily upgraded to Dymension 2 or 3 if the proteomics needs of the laboratory change.

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SOD Assay Kit - WST

NBS Biologicals Ltd.

SOD or SOD-like activity detection.  WST-1 based SOD inhibition assay, colourimetric microplate measurement, measures 100% inhibition by SOD, pH-independent IC50 determination, low background noise measurement.

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Spectra/Por Float-A-Lyser

NBS Biologicals Ltd.

Ready-to-use dialysis device with a broad built-in range of precise MWCO's and all the needed accessory components built in for ultimate convenience.  Features leak proof and re-sealable snap-on cap for sampling, colour coded dot for MWCO, broad floatation disk for buoyancy, 6 volume-specific size, 2 membrane types- biotech grade regenerated cellulose (RC) and biotech grade cellulose ester (CE).

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Apoptosis Products

Merck

Calbiochem® supplies a wide variety of products for the study of apoptosis, includingActivators and Inhibitors Antibodies and Blocking Peptides Assay Kits Caspase-related products Mitochondrial Permeability-Transition Reagents and Related Products Poly(ADP-Ribose) Glycohydrolase (PARG) Inhibitors Poly(ADP-Ribose) Polymerase (PARP) Inhibitors Telomerase Products View the online interactive pathways to easily locate the product…

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vHCS™:View

vHCS:View Module Desktop PC software is avalable separately from the full vHCS™ Discovery ToolBox. vHCS:View provides, Rich visualization of HCS data, allowing users to see spatial, temporal, morphological and phenotypic changes at the cell levelInteractive visual analysis of multi-feature, cell-based data  to the image levelLink to Spotfire® DecisionSite™ for deeper visualization and data miningMulti-plate, multi-well, multi-…

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Content Addressed Storage Module for EMC Centera™

Cellomics® Content Addressed Storage (CAS) Module for EMC Centera™ is an HCS Applications Server plug-in that provides an interface to the EMC Centera content addressed storage system. Centera is EMC’s newest storage platform specifically designed to work with large volumes of fixed content information, such as the many terabytes of images generated by HCS instrumentation. The CAS Module allows HCS image data to be seamlessly…

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Micronucleus V2 Image Analysis BioApplication for Genotoxicity

The Micronucleus V2 BioApplication is a powerful image analysis algorithm for identifying and quantitating the rare event of micronucleus formation as a measure of genotoxicity.  Because it can screen a 96-well plate in under 8 hours, it enables screening for genotoxic compounds in an automated, objective manner.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for th…

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Molecular Translocation V2 Image Analysis BioApplication for Kinase and transcription factor activation

Molecular Translocation V2 is an advanced image analysis application for quantitating simultaneous cytoplasm-to-nucleus translocation of multiple targets.  It features subpopulation selection and cross-correlated responder analysis of up to 5 distinct targets, allowing study of signaling pathways.  This application has been biologically validated, enhancing confidence in your image-based data.    Available for the Cellomics Ar…

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Morphology Explorer V2 Image Analysis BioApplication

Morphology Explorer V2 is a powerful general-purpose image analysis application for measuring size, shape, and distribution of cells, colonies, and subcellular components.  It performs sophisticated calculations in a turn-key, automated manner allowing higher throughput of complex cell-based assays.  This application has been biologically validated, enhancing confidence in your image-based data.    Available for the Cellomics…

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Cell Health Profiling V2 Image Analysis BioApplication for Apoptosis and Cytotoxicity

Cell Health Profiling V2 is a flexible image analysis application employing advanced cell-level logic to detect and classify cell health-related events.  It analyzes patterns of cellular fluorescent labeling that can be used to classify cells as undergoing apoptotic, necrotic, or other cell death mechanisms.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for the Cel…

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Cell Cycle V2 Image Analysis BioApplication

The Cell Cycle V2 BioApplication is a sophisticated image analysis algorithm that performs automated analysis of the cell cycle phase of individual and populations of cells.  It reports cell cycle phase as well as the state of up to 3 target proteins for every cell analyzed, and correlates the target data with DNA content.  This application has been biologically validated, enhancing confidence in your image-based data.  Availa…

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Cytotoxicity V2 Image Analysis BioApplication

The Cytotoxicity V2 BioApplication is an image analysis application that simultaneously measures four markers of cytotoxicity (nuclear fragmentation/condensation, permeability, lysosomal mass-pH, and cell count) and reports individual and composite indicies of cytotoxicity.  The V2 version has been enhanced with object segmentation to allow clumped cells to be efficiently analyzed.  Available for the Cellomics ArrayScan VTI, A…

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Extended Neurite Outgrowth V2 Image Analysis BioApplication for Neurobiology

Extended Neurite Outgrowth V2 is an advanced image analysis algorithm that can quantitate neurite outgrowth with features such as cell body area and branch point quantitation, cell subpopulation analysis, Ability to analyze neuron subsets expressing up to two distinct neurotransmitters.  It reports all features at the cell, well, and subpoulation level, and is biologically validated to enhance confidence in your image-based da…

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Compartmental Analysis V2 Image Analysis BioApplication

Compartmental Analysis V2 is a powerful general image analysis tool for quantitating intracellular intensity changes in specific sub-cellular regions across multiple fluorescent channels.  It performs spot analysis and reports intensity ratios and differences among sub-cellular regions and/or different fluorophores.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for…

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