Drug discovery > Target Discovery Products & Reviews

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Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.

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Epidermal Growth Factor, recombinant mouse

Merck

Epidermal Growth Factor (EGF) is a polypeptide growth factor, which stimulates the proliferation of a wide range of epidermal and epithelial cells. Recombinant murine EGF is a 6.2 kDa protein containing 54 amino acid residues.

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Glucagon RIA

Merck

Glucagon is a 3,5 kDa hormone secreted by the A cells of the Islets of Langerhans in the pancreas and is involved in regulation of glucose homeostasis thro µgh enhanced synthesis and mobilization of glucose in the liver, and regulation of glucose-stimulated insulin secretion.

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Human Adiponectin RIA

Merck

Adiponectin is identified as a 30 kDa adipokine that is secreted from the adipose tissue into circulating blood and influences systemic metabolism.

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Human Insulin-Specific RIA

Merck

Insulin, a 5.8 kDa hormone is secreted by the islet beta cells in the pancreas. This kit measures specifically human insulin with no cross-activity to intact proinsulin.

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Human Leptin RIA

Merck

Leptin is synthesized in adipocytes as a 16 kDa molecule and the circulating level is directly proportional to the total amount of fat in the body.

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Mouse Adiponectin RIA

Merck

Adiponectin is identified as a 30 kD adipokine that is secreted from the adipose tissue into circulation blood and influences systemic metabolism.

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Mouse Leptin RIA

Merck

Leptin is synthesized in adipocytes as a 16kD molecule and the circulating level is directly proportional to the total amount of fat in the body.

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Porcine C-Peptide RIA

Merck

C-peptide is a byproduct of normal insulin production by the beta cells in the pancreas and correlates directly to endogenous concentrations of insulin.

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Rat C-Peptide RIA

Merck

C-peptide is a byproduct of normal insulin production by the beta cells in the pancreas and correlates directly to endogenous concentrations of insulin.

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Rat Leptin RIA

Merck

Leptin is synthesized in adipocytes as a 16kD molecule and the circulating level is directly proportional to the total amount of fat in the body.

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Rat/Mouse PYY RIA

Merck

Peptide YY (PYY), a novel 36 amino-acid amidated hormone is a component of the complex neuroendocrine control process.

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Multi-Species Leptin RIA

Merck

Leptin is synthesized in adipocytes as a 16 kDa molecule and the circulating level is directly proportional to the total amount of fat in the body.

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Dextran Sulfate 50% Solution

Merck

Dextran Sulfate (MW 500,000) is used as an additive in probe hybridization solutions. Its presence accelerates the rate of hybridization by 10 fold. The addition of Dextran Sulfate favors the formation of probe networks, resulting in greater sensitivity during membrane-bound nucleic acid analysis. The product is supplied as a 50% (w/v) solution.

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Hybrisol® I Hybridization Solution, (50% Formamide, 6X SSC)

Merck

Hybrisol® Hybridization Solutions are pre-made, ready-to-use solutions optimized for sensitive single and multiple gene copy detection using membrane-based hybridization techniques. They are designed to give maximum signal and clean background for hybridizations performed on nylon and nitrocellulose membranes. Hybrisol® Solution contains 10% Dextran Sulfate, 1% SDS, 50% Formamide, 6X SSC, Sheared DNA, and Modified Denhardt's S…

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CpGenome Universal DNA Modification Kit

Merck

The CpGenome™ DNA Modification Kit is used to create methylation-specific sequence alterations in any DNA sample. Using chemical treatment, the kit converts all unmethylated cytosine residues to uracil. Methylated cytosine residues are unaltered in this process. Therefore, the chemically-treated DNA sequence will differ only if it was originally unmethylated in vivo. After sequence conversion, methylation specific PCR is emplo…

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