Drug discovery > Target Discovery Products & Reviews

Cell Health Profiling V2 is a flexible image analysis application employing advanced cell-level logic to detect and classify cell health-related events.  It analyzes patterns of cellular fluorescent labeling that can be used to classify cells as undergoing apoptotic, necrotic, or other cell death mechanisms.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for the Cel…

The Cell Cycle V2 BioApplication is a sophisticated image analysis algorithm that performs automated analysis of the cell cycle phase of individual and populations of cells.  It reports cell cycle phase as well as the state of up to 3 target proteins for every cell analyzed, and correlates the target data with DNA content.  This application has been biologically validated, enhancing confidence in your image-based data.  Availa…

The Multiparameter Apoptosis Kit comprises three spectrally distinct fluorophores that label cellular targets to allow assessment of cell health by looking at several biological parameters.  This kit specifically labels nuclei, f-actin, and mitochondrial mass/potential in cells.  The kit has been validated for use on Cellomics’ ArrayScan® HCS Reader but may be applied to any imaging system.  Available in Evaluation Size (Five…

The Multiparameter Cytotoxicity 1 Kit  comprises three spectrally distinct fluorophores that label cellular targets to allow assessment of cell health by looking at several biological parameters.  This kit contains indicators for nuclei, permeabilized cells, and lysosome mass/pH.  The kit has been validated for use on Cellomics’ ArrayScan® HCS Reader but may be applied to any imaging system.  Available in Evaluation Size (Five…

MIAS-2 readers are a new generation of HTS microscopy readers with an unequaled blend of sensitivity, flexibility and speed.  They are designed to cover the throughput and flexibility needs at multiple phases across the R&D value chain.  In drug discovery R&D, applications include target identification, target validation, assay development, high throughput screening, hit-to-lead, deep pharmacology and ADMET.  Unique features…

What is it?  When you plan to access our technology platform, we will assist you in validating  your assay technology  in our platform technology.  Pending on your needs, we will accept your images, your plates with samples or we will create samples according to your protocols.

Not treated (or medium binding) polystyrene surface is hydrophobic in nature and binds biomolecules through passive interactions Is suitable primarily for the immobilization of large molecules, such as antibodies, that have large hydrophobic regions that can interact with the surface Untreated microplates have a binding capacity of approximately 100 to 200ng IgG/cm2 Without lids, lids supplied separately Total volume is…

Powerful transfection reagent, based on an innovative biochemical method. Next generation of outstanding transfection reagent,  highly efficient, universal and multipurpose.

For all nucleic acids and all transfection conditions.The universal and powerful PolyMag formulation allows achieving very high transfection efficiency. It is composed by magnetic nanoparticles coated with cationic molecules. Exclusive and optimized PolyMag reagent has been successfully tested with:- All nucleic acids types: naked DNA, RNA, siRNA, ODN, etc…- Cell lines, primary and hard to transfect cells- Adherent and suspens…

CombiMag improves your transfection reagent efficiencyCombiMag reagent has been designed to be employed in association with all transfection reagents complexed with any types of nucleic acids. All cell types, even hard-to-transfect and primary cells, can be transfected using CombiMag associated to any working reagent, even if its original efficiency is low.CombiMag has been associated with many existing transfection reagents i…

FlyFectin ™ is a specifically designed and very efficient transfection reagent for insect cells. Innovative and unique, FlyFectin ™ is: •  Highly efficient with excellent reproducibility•  Multipurpose (various types of nucleic acids)•  Ideal for recombinant protein production with Baculovirus expression system•  Simple, Ready-to-use and Rapid•  Compatible with and without serum-containing culture media•  Non toxic•  Economi…

Flat bottoms with 360 µL total volume Recommended working volumes of 75 to 200 µL Treated for optimal cell attachment Nonreversible lids with condensation rings to reduce contamination Sterilized by gamma radiation and certified nonpyrogenic Individual alphanumeric codes for well identification Individually wrapped

Recommended working volume of up to 20 to 80 µL Conforms to standard microplate footprint and dimensions High binding surface binds medium (>10kD) and large biomolecules that possess ionic groups and/or hydrophobic regions Binding capacity is approximately 400 to 500ng IgG/cm2 Ideal for immunoassays

Feature uniform skirt heights for greater robotic gripping surface Solvent resistant polypropylene provides compatibility with many common organic solvents (e.g., DMSO, ethanol, methanol) Sterile and DNase- and RNase-free Total volume is 360 µL; recommended working well volume is 75 to 200 µL Without lids; lids, sealing mats and tapes supplied separately

B-Pak, is a straightforward and rapid procedure for determining the concentration of protein in solution. Thanks to an optimized Bradford reagent formulation, B-Pak gives precise determination of protein concentration even in the presence of detergent, allowing the use of this kit for transfection experiments. In addition, this kit can be used for all protein concentration measurement due to a superior linearity of response: f…

Issued from Magnetofection™ technology, ViroMag is a specific formulation designed to be used in association with all viral vectors and for many transduction applications. For the first time, scientists will be able to increase transduction efficiency, infect non permissive cells, concentrate virus onto cells or in culture medium or synchronize infection without modification of the viruses, just by associating ViroMag reagent…

miVac is a range of centrifugal vacuum concentrators and freeze driers capable of removing water and organic solvents from a variety of sample formats including tubes, microplates, and vials. miVac concentrators come in 2 sizes, the smaller Duo and a larger Quattro. There is a choice of vacuum pump and rotor according to application and sample format.  To speed concentration built-in special runs for working with water and…

Manufactured from optically clear polystyrene Threaded plug seal caps prevent leakage Treated for optimal cell attachment Tubes supplied racked in foam tray Sterilized by gamma radiation and nonpyrogenic Max RCF of 1,400xg

An easy way to assess tag accessibilityThe production of fusion proteins often raises the issues not only of their structural integrity after isolation, but also of the accessibility of the associated tag. In the case of GST or 6HIS tagged proteins, this verification can be achieved with HTRF® GST and 6HIS check kits. These two assays are competitive immunoassays in which the anti-GST or anti-6HIS Cryptate conjugates bind dire…

A new secondary messenger for Gq coupled receptor investigation.Cisbio’s IP-One assay, based on its proprietary HTRF® technology, is the first HTS immunoassay that can easily detect inositol(1)phosphate (IP1), a stable second messenger which tightly correlates with Gq-coupled receptor activity. This assay displays all the characteristic advantages of an HTRF® system: totally homogeneous, detection via fluorescence, signal stab…

A team of experts for outsourcing your assay developmentsOur Service Team at Cisbio international is highly trained in protein chemistry and fluorescent technology, and offers you its expertise in assay development to build HTRF® assays adapted to your specific targets or to convert existing assays to HTRF® technology.Assays may be developed using HTRF® toolbox reagents, custom labeled molecules or a combination of both. Most…

Rapid Analysis of Multiple 2D Gel Sets DYMENSION 2 has all the features of DYMENSION 1 but has the added ability to detect and compare protein spot maps in multiple gel sets. The software offers many background correction and noise filtering features including a SYPRO® Ruby filter, which can detect and automatically remove spots caused by SYPRO® Ruby crystals adhering to the gel, thus saving users valuable time editing the…

Quick and Easy Analysis of all 2D Gel Applications The exciting DYMENSION 3 software has all the functionality of DYMENSION 2, so can be used to analyse multiple gel sets. In addition, DYMENSION 3 is capable of analysing multi-stained fluorescent gel images stained with up to three contrasting fluorescent labels, for example, Cy™2, Cy™3 and Cy™5. This feature allows users to analyse multiple sets of any type of 2D protein…

VeroFect™ is a powerful reagent dedicated to the transfection of Vero cells. This lipid -based transfection reagent is issued from the revolutionary Tee-Technology and achieves up to 50-55% transfection efficiency. The complexes formed by DNA and VeroFect™ reagent have an exceptional capacity in destabilizing cell membranes, allowing the delivery of important DNA amounts into cells. VeroFect™ was specifically designed to obtai…

Bottoms are 60% thinner than conventional polystyrene plates, resulting in lower background fluorescent and enabling readings down to 340nm Designed to reduce well-to-well crosstalk during fluorescent assays Can be used for both top and bottom reading instruments Not treated (or medium binding) polystyrene surface is hydrophobic in nature and binds biomolecules through passive interactions Is suitable primarily for the i…