Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
Customer-owned TaqMan® assays reformatted on OpenArray® plates. Plates must be ordered in multiples of 10. Minimum order is 10 plates. Kit includes: Cases, Immersion Fluid, Case Sealing Glue and Plate-File CD.
Real-Time qPCR assays for kinases and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real-Time qPCR Case, Immersion Fluid, Frame Adhesive and Plate-File CD.
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for ADME and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real…
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Apoptosis and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate,…
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Cancer and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Re…
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Cardiovascular Disease and related genes reformatted onto an OpenArray plate. Kit includes: Ope…
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Inflammation and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray pla…
Real-Time qPCR assays for Signal Transduction and related genes reformatted onto an OpenArray plate. Kit includes: OpenArray plate, Real-Time qPCR Case, Immersion Fluid, Frame Adhesive and Plate-File CD.
An acetyl-biotinylated substrate recognized by a Eu3+ anti-acetyl MAb and SA-XL665, which is used in activator screening or to test an High Throughput SIRT1 inhibitor. The level of enzymatic activity is inversely proportional to the amount of signal produced in the system. For more information please visit Cisbio Bioassays website.
Reduced breakdown liners Our improved injection port liner reduces breakdown of endrin and DDT during injections while increasing the interval between liner changes. The problem DDT and Endrin are easily degraded in the injection port; with non-deactivated liners and those filled with non-deactivated glass wool, Endrin breakdown can be as high as 98%. EPA method 8081A states "If degradation of either DDT or Endrin exceeds 15%,…
Ambion Anti-miR™ miRNA Inhibitors are chemically-modified, single-stranded nucleic acids designed to specifically bind to and inhibit endogenous miRNA molecules. These ready-to-use inhibitors can be introduced into cells using transfection or electroporation parameters similar to those used for siRNAs, and enable detailed study of miRNA biological effects.
STN is an online database service that provides global access to published research, journal literature, patents, structures, sequences, properties, and other data.
Ambion Pre-miR™ miRNA Precursor Molecules are small, chemically-modified double-stranded RNA molecules designed to mimic endogenous mature miRNA molecules. These ready-to-use miRNA mimics, which are similar to but not identical to siRNAs, can be introduced into cells using transfection or electroporation parameters identical to those used for siRNAs and enable detailed study of miRNA biological effects via gain-of-function e…
Silencer Pre-Designed siRNAs are Ambion-designed siRNAs available for all human, mouse, and rat gene targets in the RefSeq database. These siRNAs are designed for maximum potency and specificity using a highly effective and extensively tested algorithm. Each siRNA is synthesized to the highest quality standards and is provided with full sequence information. Silencer Validated siRNAs are Ambion-designed siRNAs that have been…
Ambion Silencer Select Pre-Designed and Validated siRNAs incorporate the latest improvements in siRNA design, off-target effect prediction algorithms, and chemical modifications to yield siRNA with unrivaled efficacy, potency, and specificity. The result is fewer failed experiments due to poor silencing, and cleaner, more consistent phenotypic data.
Ambion Silencer® In Vivo Ready siRNAs undergo the additional purification and testing necessary for introduction of siRNA into animals. After HPLC purification and annealing, each siRNA is dialyzed to remove salt, sterile filtered, and endotoxin tested. All Silencer Pre-Designed and Validated siRNAs are available in this format, as are Custom Synthesized siRNAs.
Abmion Validated GAPDH Positive Control siRNA and non-targeting Negative Control siRNAs are available for human, mouse and rat with the same chemical modifications for enhanced efficacy as in other Ambion Silencer Select siRNAs.
For the first time, you can obtain the benefits of Ambion Silencer Select siRNAs in a convenient 96- or 384-well plate format, plated to your specifications. These siRNA collections enable medium- and high-throughput analysis of phenotypes resulting from inhibition of sets of targets from specific functional classes or your favorite list of targets.
Silencer siRNA Libraries are sets of Ambion-designed siRNAs targeting all of the genes in a genome or a particular gene class, making them ideal for pathway analysis and target identification/validation. Most libraries include three individual siRNAs per gene for enhanced data reliability. Full sequence information is provided with each library.
Applied Biosystems currently offers five TaqMan Copy Number Assays to detect copy number variation. Copy number is an important polymorphism in the human genome associated with genetic diseases such as cancer, immune diseases, and neurological disorders. TaqMan Copy Number Assays were designed to detect CYP2D6, CYP2A6, CYP2E1, GSTT1, and GSTM1.
The TaqMan® Custom Array is a 384-well micro fluidic card that enables a researcher to perform 384 simultaneous real-time PCR reactions without the need to use liquid-handling robots or multichannel pipettors to load. This low- to medium- throughput array allows for 1-8 samples to be run in parallel against 12-384 TaqMan® Gene Expression Assay targets that are pre-loaded into each of the wells on the array. The TaqMan Custom…
The TaqMan Custom Plating service offers the convenience of pre-plated TaqMan® Gene Expression Assays, Custom Assays, and Custom Probe/Primer Sets in 96- or 384-well plates. This cost-effective custom plating service gives you the flexibility and reliability you need for your screening applications. Whether you are looking for biomarkers, testing for toxicity, searching for microbes, or performing other high-throughput scree…
Applied Biosystems TaqMan Drug Metabolism Genotyping Assays are available for basic research and clinical research. Genotype over 2,600 high value polymorphisms located in regulatory elements and coding regions for 220 drug metabolism and transporter genes with TaqMan® Assay technology.
TaqMan® Express Plates are a cost-effective and convenient 96-well format complimenting Applied Biosystem's line of individual TaqMan® Gene Expression Assays, and pre-spotted 384-well TaqMan® Arrays. Customize any of the six available plate formats with dried-down TaqMan® Assays by positioning each in specific well locations. This flexibility enables an efficient means to screen biological samples for the presence and amount…
TaqMan® Gene Sets are pre-defined lists of genes grouped by pathway or disease target class which can be ordered separately, as a custom plate, or configured directly onto TaqMan® Arrays to enable you to perform hundreds of real-time PCR reactions simultaneously on the Applied Biosystems 7900HT Fast Real-Time PCR System. Simple to implement, TaqMan Gene Sets are customizable, and when placed on a TaqMan Array, require mini…
