ADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
The ToxReporter Cell Line Starter Pack 8 (Catalog # ECLSP-008) includes ToxReporter ARE Stimulant (Catalog # ESTM-008), Selection Agent (Catalog # ESA-001), and Assay Media Supplement (Catalog # EAMS-001). Each component is sufficient for 100 assay points. If needed, each individual component may be purchased separately. ToxReporter Cell Line Starter Pack 8 is required for use with the ARE ToxReporter Cell Line (Catalog # EC…
One vial of ToxReporter XRE Stimulant (Catalog # ESTM-007) contains 100 µL of 100 µM 3-methylchoranthrene in 10% DMSO at 100X concentration. One vial of ToxReporter Selection Agent (Catalog # ESA-001) contains 20 mL of proprietary selection compound at 100X concentration. One vial of Assay Media Supplement (Catalog # EAMS-001) contains 1 mL of proprietary reagent at 100X concentration. ToxReporter Cell Line Starter Pack 7 is…
The ToxReporter Cell Line Starter Pack 6 (Catalog # ECLSP-006) includes ToxReporter HRE Stimulant (Catalog # ESTM-006), Selection Agent (Catalog # ESA-001), and Assay Media Supplement (Catalog # EAMS-001). Each component is sufficient for 100 assay points. If needed, each individual component may be purchased separately. ToxReporter Cell Line Starter Pack 6 is required for use with the HRE ToxReporter Cell Line (Catalog # E…
This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…
This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…
This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…
This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…
This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…
Experience Better Productivity and Save Resources Too RapidFire data correlates identically with traditional LC-MS/MS methods Analyses are performed at a 10+ fold increase in cycle throughput, enabling us to provide 3 day turnaround RapidFire In Vitro ADME Analysis Services increase efficiencies while preserving your lab’s assay method integrity. We use the RapidFire 360 high-throughput TOF system to analyze CYP inhibition/ind…
This kit enables simultaneous measurements in the same cell of six independent parameters that monitor cell health, including cell loss, nuclear size and morphological changes, mitochondrial membrane potential changes, cytochrome c release, and changes in cell permeability.
The BrdU and Ki67 Cell Proliferation HCS Reagent Kits are for simultaneous quantification of DNA replication and Ki67 proliferation marker in the same cell.
The Multiparameter Cell Death Detection Kits for high-content screening (HCS) enable simultaneous quantitation of LC3B protein on autophagic vesicles, cytochrome c localization and its release from mitochrondria, cell membrane integrity and its permeability and nuclear morphology and DNA content.
The micronucleus assay is an important component of genetic toxicology screening programs. Micronuclei arise from acentric chromosomes and lagging whole chromosomes.
The Autophagy & Proteasome Function: LC3B and Poly-Ubiquitin Detection Kits enable quantitation of LC3B protein on autophagic vesicles and ubiquitin on polyubiquitinated proteins.
The iNOS Activation Kits measure cytoplasmic induction of the iNOS enzyme via activation of one of the many inflammatory pathways.
The Cellomics Phospho-ATM Activation Kit contains optimized reagents for the detection and quantitation of phosphorylated ATM (Ser1981) in the nuclei.
The Mitotic Index HCS Reagent Kit provides high-content screening (HCS)-quality fluorescence reagents and a validated protocol for measurement of mitotic index, or the fraction of cells undergoing cell division within a population.
Micro-ruled coverslip for cell culture with microscopic identification and measurement markers.
BlueScreen HC is based on the fast, accurate GreenScreen HC genotoxicity assay from Gentronix Ltd. BlueScreen HC uses the same human-derived, p53-competent TK6 cells to host a patented reporter system that exploits the proper regulation of the GADD45a gene. However, in place of GFP, BlueScreen HC utilizes a luciferase from the marine copepod Gaussia princeps to generate a luminescent output. The BlueScreen luminescent assa…
Predict pharmacokinetic properties from structure
High Content Analysis (HCA) is rapid, automated microscopy providing quantitative image acquisition and analysis. Using Millipore’s superior-quality reagents in ready-to-use kits and cell-based assays that incorporate the power of HCA, researchers around the world are able to learn more about relevant functional cell biology in many different systems, including assessment of DNA damage and apoptosis. Millipore’s HCA kits inclu…
BlueScreen HC uses a single cell strain, which permits 8 compounds to be tested across 8 dilutions (2-fold serial), together with untreated and positive controls, in one 96-well microplate. After arraying test compounds and dilutions, growing cells are added to each well. For studies without S9 metabolic activation data are collected after incubation (48h) using a multimode microplate reader. For studies incorporating S9 metab…
The cost of drug discovery continues to rise while the output of new NDAs continues to fall. Consequently it has never been more important to address attrition rates in drug discovery and development. Early indication of toxicity in a molecule or lead family means that discovery resources can be directed either at other chemical series if these are available or towards ‘breeding’ out undesirable properties. Gentronix and Apred…
FasL-Strep, a stable homotrimer, efficiently induces the CD95 pathway of apoptosis and is highly suited for evaluation of CD95 (Fas) receptor-ligand interaction. Human or murine FasL-Strep (CD95L-T4) is an engineered human or murine Fas (CD95) ligand. C-terminal fusion of the T4-FOLDON to the extracellular FasL (CD95L) receptor-binding domain (E142-L281) results in bioactive, conformationally stabilized, well defined trimers…
