ADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
DNAQual kit is used for the quantitative assessment of DNA degradation by quantifying the number of copies of a target gene compared to a calibrator gene (included in the kit) in any human DNA sample by qPCR in duplex in 90 minutes. The two genes (target and calibrator are measured with two specific probes carrying each a different fluorophore: Texas Red for the calibrator and VIC for the target gene. The software on the qPCR…
Pursue preliminary appraisal of your drug candidate's safety with Covance's Lead Optimization (LO) Toxicology services. Whether your screening needs are for traditional dosing and observation methods or technologically sophisticated services, Covance LO Toxicology services, Safety Assessment and Abuse Liability provides you with sophisticated preclinical measurements of cardiovascular, endocrine, behavioral or neural function…
Capitalize on the intricacies of research questions honed over thousands and thousands of in vivo pharmacology studies conducted by Covance. Procure Covance's in vivo pharmacology expertise and capabilities for your benefit in the design, validation, conduct, and analysis of animal efficacy pharmacology studies for your drug candidates.Lead Optimization Pharmacology Service Features: Assessing and engaging the target tiss…
Camargo ensures the appropriate regulatory requirements are met every step of the way, streamlining your drug development process all the way to approval.Ready to guide you through the preclinical stage of drug development, Camargo provides strategic support in the following areas: CRO selection Study design Study setup and execution Project management In clinical program development, camargo's focus is unwavering:…
Hepregen offers a range of DMPK services using their HepatoPac™ co-culture system. Hepregen has experienced scientific staff which work closely with our clients to design assays that meet their needs. We take great pride in our quality results and impeccable customer care. If you don't see your application of interest, our scientists can work with you to create a custom assay.DMPK Services: Metabolite Identification Intr…
Hepregen offers a range of toxicology services using their HepatoPac™ co-culture or Kupffer Cell Model systems. Hepregen's experienced scientific staff work closely with clients to design assays to meet their needs. Hepregen take great pride in their quality results and impeccable customer care. If you don't see your application of interest, their scientists can work with you to create a custom assay.Toxicology Services:…
Assessment of Neuronal Activity Using Microelectrode Array. The eCiphrNeuro assay uses primary cultures of rat cortical neurons. Cyprotex’s neuronal assay uses high throughput microelectrode array (MEA) technology to monitor electrophysiological activity. Neurons grown on microelectrode arrays recapitulate many features of neurons in vivo, including spontaneous activity (spiking and bursting), plasticity, organisation a…
At Peakdale we offer a range of in vitro ADMET predictive models, delivering accurate and reproducible data, maintaining a focus on efficient turnaround times to facilitate our customers' drug discovery programs. In addition to our core assays, we also offer our clients the flexibility of bespoke assay design. The majority of our assays utilise sensitive "state of the art" triple quad LC-MS/MS ESI detection. Complementing our…
The Biocrates® Vitamin D Kit provides ready-to-use components for a LC-MS/MS-based assay and enables the quantitative measurement of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3. The inability to differentiate between 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 is the main drawback of immune-based techniques. The separate measurements are useful for both, clinical and research purposes. Moreover, the cross reactivity with…
Detect caspase-1 activity with the FLICA® Caspase 1 Assay Kit. This in vitro assay employs the green fluorescent inhibitor probe FAM-YVAD-FMK to label active caspase 1 enzyme in living cells or tissue samples. Analyze the fluorescent signal using fluorescence microscopy, a fluorescent plate reader, or by flow cytometry. Caspase 1 (ICE):Members of the mammalian caspase family of cysteinyl aspartate-specific proteases play disti…
