ADME-Toxicology Products & Reviews

Live-cell analysis system

High-throughput live-cell analysis system

A far-red viability dye staining nuclei in dead / apoptotic cells.

Ready-to-use, dropper bottle far-red viability probe

Apoptosis is a normal physiologic process which occurs during embryonic development as well as in maintenence of tissue homeostasis. The apoptotic program is characterized by certain morphologic features, including loss of plasma membrane asymmetry and attachment, condensation of the cytoplasm and nucleus, and internucleosomal cleavage of DNA. Loss of plasma membrane is one of the earliest features. In apoptotic cells, the mem…

The LUNA-STEM™ takes adipose-derived stem cell and SVF samples to count live nucleated cells, dead nucleated cells, and non-nucleated cells with precision and consistency for downstream procedures.

Yeast strains used in food and drink production can be notoriously clumpy.  The LUNA-II YF™ has an autofocusing cell counting and declustering algorithm that counts individual yeast cells in just 15 seconds.

PhysioMimix™ microphysiological systems generate in vitro microtissues that mimic the structure and function of human tissues and organs. Through the simulation of human biological conditions, they bridge the gap between traditional cell culture and human studies, reliably predicting drug effects to facilitate the accelerated development of safe and efficacious therapeutics. 

The ApoTox-Glo™ Triplex Assay combines three assay chemistries to easily assess viability, cytotoxicity and apoptosis events in the same cell-based assay well. First, viability and cytotoxicity are determined by measuring two differential protease biomarkers simultaneously with the addition of a single nonlytic reagent containing two peptide substrates. The live-cell protease activity is restricted to intact viable cells and i…

The Griess Reagent System measures nitrite (NO2–), which is one of two primary stable and nonvolatile breakdown products of nitric oxide (NO). Nitric oxide is an important physiological messenger and effector molecule in many biological systems, including immunological, neuronal and cardiovascular tissues. This assay relies on a diazotization reaction that was originally described by Griess in 1879. Through the years, many mod…