Oncology Animal Models Products & Reviews

The Newton 7.0 is a cutting-edge optical imaging system that offers the versatility to perform bioluminescence, fluorescence, and 3D tomographic imaging in a single device. Its user-friendly interface and advanced features make it ideal for in vivo, ex vivo, and in vitro imaging applications, as well as simultaneous imaging of multiple specimens.

The Washington University Human In Mouse (WHIM) Breast Cancer PDX Model Collection and the Wistar Melanoma (WM) PDX Models are exclusively available from Inotiv. 

The CD34 humanized NSG-FLT3-IL15 (F15) mouse is the most comprehensive immune cell mouse model from the Jackson Laboratory to date.

In vivo model for xenograft and Immunology studies. Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.Rag1 Knockout Rat Characteristics: 29 bp deletion within Exon 2 on chromosome 3 Homozygous Rag1 k…

The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. Mature B and T cells are critical components for an adaptive immune system. DNA-PK kn…

Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease. ApoE Knockout Rabbit Characteristics: 8 bp deletion within Exon 3 Homozygous knockouts exhibit complete loss of ApoE protein via Western bl…