Oncology Animal Models Products & Reviews

The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging in small animals such as mice and rats. This compact and cost-effective tablet-based system provides high-resolution images (up to 30 µm) and advanced capabilities to monitor changes in hemodynamics and observe anatomical structures in real-time.

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010. Model Properties: Coat Color: Hairless, albino background…

In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies. Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.ApoE Knockout Rat Characteristics: 16 bp deletion wit…

Take advantage of our large inventories of common inbred strains and the convenience of having your breeding and drug efficacy needs met by the leading experts in mouse modeling.

3D Live Cell Perfusion Culture System

Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to triggers colitis in mice and rats when administered in drinking water.  

The M-Series™ systems are cryogen/cooling-free, self-shielded, high-performance MRI systems based on permanent magnet technology. The M-Series systems allow preclinical researchers, with or without in-depth knowledge of MR physics, to utilize the gold standard method in soft tissue imaging without the cost, complexity, and technical burden of superconducting MRI systems. 

The NEWTON FT-900 is a deeply cooled CCD imager dedicated to SWIR (NIR-I, NIR-II), fluorescence and bioluminescence multi-spectral imaging as it allows for in vivo applications in the visible, near and short-wave infrared spectrum (VIS/ NIR/ NIR-II). Smart and ultra sensitive, it provides non-ionizing and non-invasive visualization of biological processes in real-time.

The TriTom imaging platform utilizes photoacoustic and fluorescence tomographies (PAFT) for high-resolution, non-invasive whole-body imaging in small animal models, achieving up to 160 µm resolution. This multi-modality system enables simultaneous acquisition of photoacoustic and fluorescence data in large volumes (> 25 cm3), allowing for spectroscopic molecular analysis. 

The SuperArgus PET/CT is a high-performance imaging system it can be configured as a combined PET/CT or PET or CT only system, and features state-of-the-art phoswich PET detectors with true depth-of-interaction (tDOI) for resolution uniformity and high sensitivity. The system offers real-time imaging up to 2.5msec frame rate and advanced capabilities like sensorless cardiac gating and conscious/awake imaging.

The Newton 7.0 is a cutting-edge optical imaging system that offers the versatility to perform bioluminescence, fluorescence, and 3D tomographic imaging in a single device. Its user-friendly interface and advanced features make it ideal for in vivo, ex vivo, and in vitro imaging applications, as well as simultaneous imaging of multiple specimens.

The Washington University Human In Mouse (WHIM) Breast Cancer PDX Model Collection and the Wistar Melanoma (WM) PDX Models are exclusively available from Inotiv. 

The CD34 humanized NSG-FLT3-IL15 (F15) mouse is the most comprehensive immune cell mouse model from the Jackson Laboratory to date.

In vivo model for xenograft and Immunology studies. Recombination Activation Genes (Rag) encode enzymes that play an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the process of V(D)J recombination. Rag1 knockout rats lack mature B and T lymphocytes.Rag1 Knockout Rat Characteristics: 29 bp deletion within Exon 2 on chromosome 3 Homozygous Rag1 k…

The Prkdc gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). DNA-PK is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. Mature B and T cells are critical components for an adaptive immune system. DNA-PK kn…

Rabbits are a preferred model in hypertension and atherosclerosis studies due to their convenience of various physiological and surgical manipulations. ApoE Knockout rabbits have drastically elevated cholesterol and triglycerides, making it an excellent model of human heart disease. ApoE Knockout Rabbit Characteristics: 8 bp deletion within Exon 3 Homozygous knockouts exhibit complete loss of ApoE protein via Western bl…