Biomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :
Sino Biological offers a wide range of products and services to provide customers with complete multispecific antibody development solutions covering various phases of the development process, such as antibody development and optimization, druggability assessment, animal model evaluation, and process development.
Sino Biological provides comprehensive solutions for CAR-T cell therapy companies from CAR development, T cell activation, lentivirus packaging, CAR-T cell expansion to CAR-T cell quality control, fully supporting CAR-T research.
Sino Biological has developed a series of high-quality research reagents for dominant SARS-CoV-2 mutants, including recombinant antigens, detection antibodies, ELISA kits, pseudovirus, cDNAs, peptide pools, and receptor ACE2. These variant reagents have actively supported the basic research of SARS-CoV-2 and the development of vaccines, therapeutic antibodies, and diagnostic reagents.
Sino Biological provides comprehensive reagents and services for CAR-NK cell therapy development to support our customers from early target discovery to the preclinical phase of research and development.
Cytokines and their receptors show great potential in tumor immunotherapy, and many cytokines have been identified as targets for tumor drug development. Sino Biological's cytokines support stem cells, neural cells, immune cells, and organoids, facilitating functional studies and accelerating scientific discoveries.
Sino Biological has developed an extensive suite of recombinant complement proteins, covering C1s, C2, C3, C5, C7, Factor B, D, H, I and more, advancing the development of novel treatments targeting complement proteins.
Sino Biological offers a comprehensive range of recombinant HER3 proteins and antibodies, facilitating studies on HER3 signaling, protein-protein interactions, and drug efficacy assessments.
Sino Biological provides a comprehensive range of recombinant CEACAM proteins and corresponding CEACAM antibodies for crucial research, aiding investigations into CEACAM interactions with pathogens and their potential in new medical discoveries.
Millipore now proudly offers the MILLIPLEX® MAP Human Cancer Biomarker Panel. The Cancer Biomarker Panel includes both a Five-Plex assay, which simultaneously measures five serum biomarkers, Macrophage Migration Inhibitory Factor (MIF), Prolactin, CA-125, Leptin and Osteopontin (OPN), and a Single Plex IGF-II assay. The combination of the six serum biomarkers that discriminate between disease-free and ovarian cancer patien…
STN is an online database service that provides global access to published research, journal literature, patents, structures, sequences, properties, and other data.
The mTRAQ™ Reagents are duplex amine-specific, stable isotope labeled reagents designed for high confidence protein and peptide biomarker verification using MRM analysis on the QTRAP® system and the triple quadrupole mass spectrometers. * Duplex mass difference tags (Non-Isobaric Amine Tags) * Established chemistry with > 95% labeling efficiency * High selectivity MRM based relative quantitation of proteins/peptides/PTMs * Sup…
Innova Biosciences – Antibody Conjugation Service Bio-conjugates can be challenging to optimise and time consuming to produce: 1. Too much conjugation may result in the target protein becoming inactive and insoluble. 2. Too little conjugation can result in weak signals. 3. Our competitors require milligrams of your precious material and have a 2 week process time. Fast & FAb™ Antibody Conjugation Service – Innova Biosciences t…
R&D TNF-alpha / TNFSF1A - Recombinant Human Protein Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. Specifications and Use for R&D TNF-alphaSource of R&D TNF• A DNA sequence encoding the mature human TNF-α protein sequence (Accession…
R&D Systems Recombinant Human LDL RThe low density lipoprotein receptor (LDLR) is the founding member of the LDLR family of scavenger receptors. This family contains transmembrane molecules that are characterized by the presence of EGF repeats, complement-like repeats, and YWTD motifs that form β-propellers. Specifications and Use for R&D LDL RSource of R&D LDL R• A DNA sequence encoding the signal peptide from human CD33 was…
R&D Systems Recombinant Human IL-1 beta/IL-1F2 IL-1 is a name that designates two pleiotropic cytokines, IL-1α (IL-1F1) and IL-1β (IL-1F2), which are the products of distinct genes. IL-1α and IL-1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. S…
TGF- β1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-β superfamily that share a characteristic cystine knot structure.1 - 7 TGF-β1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Specifications and Use for R&D TGF-beta1Source •…
Say goodbye to secondary antibodies – Go direct using the World’s Easiest DIY Antibody Labeling Kit - Lightning-Link™! • Eliminates need for secondary antibodies • Reduces the number of wash steps • Ideal for multi-protein analysis – with over 40 available labels • Very easy to use • 100% antibody recovery Lightning-Link™ kits The DIY Lightning-Link™ kit allows you to label an antibody with minimal hands-on time - less than 30…
LifeXtend™ conjugate stabilizer/diluent is a proprietary multi-component reagent system that stabilizes antibody-HRP conjugates both at 4°C and at ambient temperature. By using LifeXtend™ HRP stabilizer/diluent in antibody conjugation the HRP conjugate can be stabilized during use and stored as pre-diluted, ready-to-use reagents thus eliminating waste and improving consistency from experiment to experiment. LifeXtend™ shows…
Thermo Scientific Pinpoint software is designed to simplify the transition from early-stage biomarker discovery to larger-scale, quantitative verification of putative biomarkers and general quantitative proteomics. It takes advantage of the power of Thermo Scientific TSQ triple quadrupole mass spectrometers to generate high-confidence quantitative data. Pinpoint software is in final stages of development; but for a limited t…
1 x 96-well plate, includes coupled magnetic beads and detection antibodies, buffers, lysis factor QG, diluent, streptavidin-PE, 96-well flat bottom plate, and plate seals for the detection of 9 MAPK pathway markers
R&D Oncostatin MOncostatin M (OSM) is a member of the IL-6 subfamily of cytokines that includes IL-6, IL-11, LIF, CNTF, CLC, and Cardiotrophin-1. These cytokines have overlapping biological functions and shared receptor components. Mouse OSM protein shows 48% amino acid identity with human OSM.
A miniaturized immunoassay capable of simultaneously evaluating multiple biomarkers in a single sub-array. This multiplex assay measures a panel of 10 cytokines: IL- 1α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IFNγ and TNFα plus a positive and a negative control.
A miniaturized immunoassay capable of simultaneously evaluating multiple biomarkers in a single sub-array. This multiplex assay measures a panel of 10 angiogenesis proteins: ANG, EGF, FGF, HB-EGF, HGF, IL8, Leptin, PIGF, VEGF, and G-CSF plus a positive and a negative control.
