ADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
TO-PRO3 Ready Flow Reagent is a bright, easy-to-use nucleic acid stain for distinguishing dead cells from live cells in flow cytometry assays. TO-PRO3 Ready Flow Reagent can only enter cells that have lost membrane intergrity (e.g., dead cells). Once inside, it can bind with nucleic acids, emitting a red fluorescence, which has an excitation/emission maxima of 642/661 nm, similar to Alexa Fluor™ 647 or allophycocyanin (APC).Fe…
SYTOX AADvanced Ready Flow Reagent is a high-affinity nucleic acid stain for the detection of dead cells in flow cytometry. SYTOX AADvanced Ready Flow Reagent can only enter cells that have lost membrane intergrity (e.g., dead cells). Once inside, it can bind with nucleic acids, emitting a red fluorescence, which has an excitation/emission maxima of 546/647 nm. The SYTOX AADvanced Ready Flow Reagent dye is spectrally similar t…
SYTOX™ Dead Cell Stain Sampler Kit contains sample sizes of five nucleic acid stains to identify the most appropriate satin to work in multi-color experiments. Stains include: SYTOX Blue (for the 405 nm violet laser), SYTOX Green (for the 488 nm blue laser with green emission), SYTOX Orange (for the 532 nm green laser), SYTOX AADvanced (for the 488 nm blue laser with red emission), and SYTOX Red (for the 633/5 nm red laser).St…
Annexin V Alexa Fluor 488 Ready Flow Conjugate is a bright, easy-to-use stain for apoptosis with high affinity for phosphatidylserine (PS), which becomes exposed on the outer leaflet of cells undergoing apoptosis. The Annexin V Alex Fluor 488 conjugate is excitable at 495 nm with an emission peak at 519 nm.FeaturesStable at room temperatureConvenient, ready-to-use format—no need to dilute, weigh, or pipetteCan be added directl…
Annexin V Alexa Fluor 647 Ready Flow Conjugate is a bright, easy-to-use stain for apoptosis with high affinity for phosphatidylserine (PS), which becomes exposed on the outer leaflet of cells undergoing apoptosis. The Annexin V Alex Fluor 647 conjugate is excitable at 650 nm with an emission peak at 665 nm.FeaturesStable at room temperatureConvenient, ready-to-use format—no need to dilute, weigh, or pipetteCan be added directl…
Annexin V APC Ready Flow Conjugate is a bright, easy-to-use stain for apoptosis with high affinity for phosphatidylserine (PS), which becomes exposed on the outer leaflet of cells undergoing apoptosis. The Annexin V APC conjugate is excitable at 650 nm with an emission peak at 660 nm.FeaturesStable at room temperatureConvenient, ready-to-use format—no need to dilute, weigh, or pipetteCan be added directly to Ca2+-containing me…
Annexin V Pacific Blue Ready Flow Conjugate is a bright, easy-to-use stain for apoptosis with high affinity for phosphatidylserine (PS), which becomes exposed on the outer leaflet of cells undergoing apoptosis. The Annexin V Pacific Blue conjugate is excitable at 410 nm with an emission peak at 455 nm.FeaturesStable at room temperatureConvenient, ready-to-use format—no need to dilute, weigh, or pipetteCan be added directly to…
Available in 25, 100 or 300 test packs. Annexin V (or Annexin A5) is a member of the annexin family of intracellular proteins that binds to phosphatidylserine (PS) in a calcium-dependent manner. PS is normally only found on the intracellular leaflet of the plasma membrane in healthy cells, but during early apoptosis, membrane asymmetry is lost and PS translocates to the external leaflet. Fluorochrome-labeled Annexin V can t…
ProQinase's CL100-ProliFiler is a standard service package comprising IC50 determination of your test compounds on the proliferation response of a defined panel of 100 tumor cell lines.
0.4%, liquid, sterile-filtered, suitable for cell culture
