UHPLC and HPLC Products & Reviews

The ACQUITY UPLC® Fluorescence (FLR) Detector brings unrivaled sensitivity and selectivity to UPLC®. The detector’s innovative flow-cell design, low-noise electronics and support for high-speed data rates are perfectly suited to the efficient separations of the ACQUITY UPLC's advanced fluidics technology. Target applications include PAHs, environmental contaminants, vitamins, aflatoxins and pharmaceuticals. Ultra Performance i…

SymmetryShield™ Columns feature Waters' patented embedded polar group technology that shields the silica's residual silanols from highly basic analytes at improves overall peak shape. Additionally, by placing the embedded polar group close to the silica surface, the activity of the surface silanols is further reduced. This imparts selectivity and retention that is different compared to the Symmetry C18 ligand. Embedded polar…

Reversed-Phase Protein/Peptide Columns

Over 50 years of reproducible performance

Semi-preparative Columns with excellent batch-to-batch reproducibility

Polynuclear Aromatic Hydorcarbons (PAHs) are among the most frequently monitored environmental contaminants. Waters PAH columns are optimized for the HPLC analysis of PAHs. These columns achieve baseline resolution and excellent peak symmetry for 16 different target analytes in less than 25 minutes, while employing a simple water/acetonitrile binary gradient method. The resolving power of the PAH columns provides superior pe…

The popular Bondapak® C18 chemistry and Porasil® silica packing material are available in three different particle sizes, 10, 15-20, 37-55 micron, providing easy transfer of chromatography methodology from one particle size to another. You can utilize your existing 10 micron Bondapak or Porasil chromatography as a starting point for scale-up or, if you are developing a new purification protocol, investigate which preparative…

These columns provide accurate and precise molecular weight calculations in under 7 minutes! - Fast, accurate and precise molecular weight determinations - Increase sample throughput - Greatly decrease solvent consumption and disposal

The Envirogel high-efficiency GPC cleanup columns are specifically designed to remove low volatility, high molecular weight interferences, such as lipids and natural resins, from environmental samples as specified in EPA Method 3640A. In the past, the cleanup procedure for environmental samples was performed on low-efficiency GPC columns based on packing particle diameters of 37-75 micron (200 to 400 mesh) Bio-Beads S-X resins…

For applications where the sample is neither volume or concentration limited, Waters offers 1 and 2mm Internal Diameter columns of various lengths for use on traditional HPLC MS inlets.As with Waters array of NanoEase™ columns, the same Waters reversed-phase packings are also available in these two column internal diameter offerings. Chemistry choices include: XBridge® Columns, CORTECS® Columns, XSelect Columns, Atlantis® Pola…

MassPREP™ On-Line Desalting Cartridges are an effective tool for the successful desalting of acidic, basic, and large globular proteins. The overall MassPREP™ desalting strategy provides an easy, fast (< 3 minutes), and reproducible approach for the effective desalting of proteins stored in physiological salt buffers prior to high resolution ESI-MS structural analysis.

The 515 HPLC pump is a programmable, free-standing HPLC pump available in isocratic, gradient, and semi-preparative configurations: • Precise stepper motor control (48 steps/µL resolution) of dual reciprocating pistons • Non-circular drive gears provide smooth, uniform eluent delivery • User-programmable flow rate calibration and compressibility compensation factors ensure straightforward pump operation qualification • Tests t…

The patent-pending EXP® Trap Column is rated for use at 20,000+ psi (1,400+ bar). This unique design connects directly to any injection valve (with 10-32 threads) or in-line with 1/16” stainless tubing for unparalleled convenience and efficiency. The EXP® Cartridge System enables chemists to quickly remove detergents or salts which can affect the ionization process in MS work. This trapping technique can concentrate the sampl…

OPTI-MAX® Cartridge Check Valves are designed to offer maximum performance and ease of use. From the sharp, consistent threads on OPTI-MAX® custom housings, to the exacting standards used to match ball/seat sets in OPTI-MAX® cartridges, every aspect of design and manufacturing reflects an unavoidable fact: when it comes to reliable check valve operation, quality and precision make a big difference. OPTI-MAX® check valves offer…

The entire EXP® Stem Trap and reusable holder are only slightly larger than a standard HPLC fitting. Its slim architecture allows it to easily fit into crowded instrument compartments or to connect directly to tightly-spaced injection ports. When tightened by hand, the EXP® Stem Trap seals to 8,700+ psi. All configurations incorporate wrench-flats to enable flawless sealing to 20,000+ psi (1,400+ bar). The unique packed floati…

The EXP® Fitting System is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools to a…

The EXP® Hex Head Nut & Titanium Hybrid Ferrule fitting system is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the s…

The EXP® Hand Tight Coupler is the premier adjustable nut and ferrule compression fitting for extreme high-pressure connections between 1/16" tubing and any 10-32 port. The patent-pending Titanium Hybrid Ferrule integrates the resilience of titanium with the proven sealing ability of PEEK in a superb one-piece design. The Hybrid Ferrule provides a perfect seal with every connection, yet the swage can be released without tools…

The EXP® Stem Filter features a choice of frit porosities integrated with our patented auto-adjusting stem for repeated ZDV connections with any 10-32 port. The entire filter stem and reusable holder are only slightly larger than a standard HPLC fitting. This slim architecture allows it to easily fit into crowded instrument compartments, tightly spaced injection ports, and anywhere else you need an extra level of protection ag…

The EXP® Nano Trap System is designed to remove detergents or salts which can affect the ionization process in MS work rated for routine use up to 20,000 psi.The new nano-scale traps are available in two formats – EXP® Nano Trap and EXP® Nano Trap HR. Both formats are available in 10 or 20 mm lengths and in a variety of bed volumes ranging from 0.25µL - 4.0µL. The EXP® Nano Trap follows a traditional trap column format, design…

The EXP® Hand Tight Nano Fittings System offers hand-tight and hex head adjustable nut and ferrule compression fittings for extreme pressure connections between 1/32” stainless steel tubing and 6-40 ports.Ideal for nano-scale UHPLC and UHPLC/MS, this nut and ferrule compression fitting is rated to 20,000+ psi (1400+ bar). The patent-pending EXP® 1/32” Titanium Hybrid Ferrule combines the sealing capability of PEEK and robust n…

The EXP® Nano Fittings System offers hand-tight and hex head adjustable nut and ferrule compression fittings for extreme pressure connections between 1/32” stainless steel tubing and 6-40 ports.Ideal for nano-scale UHPLC and UHPLC/MS, this nut and ferrule compression fitting is rated to 20,000+ psi (1400+ bar). The patent-pending EXP® 1/32” Titanium Hybrid Ferrule combines the sealing capability of PEEK and robust nature of ti…

OPTI-MAX® Cartridge Check Valves are designed to offer maximum performance and ease of use. From the sharp, consistent threads on OPTI-MAX® custom housings, to the exacting standards used to match ball/seat sets in OPTI-MAX® cartridges, every aspect of design and manufacturing reflects an unavoidable fact: when it comes to reliable check valve operation, quality and precision make a big difference. OPTI-MAX® check valves offer…

OPTI-SOLV® Reservoir Filters employ a unique conical design inside the filter housing to prevent air bubbles from getting trapped and disturbing your analysis. While the availability of HPLC-grade solvents diminishes the need for pre-filtering, it is still imperative that a filtration device be installed in the reservoir. Placing a filter in the reservoir is an economical way to filter particles that may result from buffer sal…

A solid PTFE body keeps OPTI-SOLV® filter at the base of the bottle where a bottom-mounted titanium frit provides unrestricted solvent access. As always, Optimize makes installation as simple as possible - no tools or fittings required and includes 5 feet of pre-installed PTFE tubing. OPTI-SOLV Reservoir Filters employ a unique conical design inside the filter housing to prevent air bubbles from getting trapped and disturbing…