ADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
CYRIS monitors and analyzes several key cellular parameters in real-time and label-free. Cell viability, metabolism, and morphology can be screened in a fully automated and atmosphere-controlled environment. The incubator integrated solution measures oxygen, pH, and cellular impedance in a multiwell plate and makes through a digital inverse microscope phase-contrast like live-cell images.
The kit is designed to use with Agilent Seahorse XF Pro analyzer for easily identifying drug-induced mitochondrial toxicity, to de-risk your drug pipeline. It provides high sensitivity and specificity, reducing false positive and false negatives. It is applicable to screen compound libraries with a throughput of 80 compounds per plate. Assay performance metrics Z’ of > 0.5 is achievable following our assay workflow.
Selvita’s in vivo team has long standing experience in the areas of infection, inflammation and fibrosis and has contributed to numerous preclinical and clinical candidates. Over 60 animal models in mice, rats, and rabbits are fully characterized and validated with clinically relevant pharmacological controls whereas in-depth expertise in translational biomarker selection and validation gives confidence in the smooth transi…
Quantify effector to target cell binding, phenotypic changes, and killing, all in a single label-free assay.
A push-button, automated solution for profiling cell health, death, apoptosis and necrosis, label-free
A push-button solution to analyze lipid droplet dynamics, label-free.
Apoptosis, or programmed cell death, is a highly regulated pathway that is important in normal developmental processes as well as many diseases. Cells undergoing apoptosis are identifiable by a number of characteristics, including changes in mitochonrial membrane potential, transport of phosphatidylserine (PS) to the membrane surface, activation of caspase proteases, and DNA fragmentation in the nucleus. Guava offers four apop…
Guava Technologies' ViaCount assay is revolutionizing the way cell counting and viability assessment are done in today's laboratories. Fast, automated, and highly reproducible, the Guava ViaCount assay addresses many of the difficulties of conventional cell counting and viability assessment methods. The Guava ViaCount assay provides: Cell counts up to ten times faster than manual counting, in a convenient turnkey assay.…
Cell viability and cytotoxicity detection. Colourimetric microplate assay, one solution type, no washing required, no radioisotopes or organic solvents required.
Gentronix has launched a new, accurate and fast in vitro mammalian cell genotoxicity assay - GreenScreen HC. The TK6 host cells are p53 competent and familiar to most genetic toxicology laboratories. A patented GFP reporter system exploits the proper regulation of the GADD45a gene. The assay delivers both high specificity and high sensitivity and detects all common mechanistic classes of genotoxin. The 96-well microplate for…
