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High-throughput sialylation screening for expediting the clone selection process

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Octet® Protein L (ProL) Biosensors are designed for rapid and direct quantitation of a broad set of kappa light chain containing IgG proteins, including whole molecules, FAb fragments and single chain variable fragments, in buffer or complex matrices. Octet® ProL Biosensors are offered in a tray format. Each tray contains 96 biosensors.

The Octet® Anti-Glutathione-S-Transferase (GST) Biosensors are designed for quantitation and kinetic characterization of GST-tagged biomolecules. Octet® GST Biosensors are offered in a tray format. Each tray contains 96 biosensors. Larger orders include discounts. The 5-tray pack represents a 10% per tray discount; 20-tray case represents a 20% per tray discount.

Taking advantage of the wide-spread use of poly-histidine protein tags (HIS-tag) in the bio-pharmaceutical industry, the Octet® NTA Biosensors further facilitates easy detection and rapid characterization of HIS-tagged molecules. Pre-immobilized with nickel-charged tris-nitriloacetic acid (Tris-NTA), the Octet® NTA Biosensors enables direct quantitation of HIS-tagged proteins and their easy capture for subsequent kinetic anal…

Octet® FAB2G biosensors come pre-immobilized with a high-affinity ligand that is specific for the CH1 region of Human IgG. The anti-human CH1 ligand has no recognition towards free light chains or cross-reactivity with murine or bovine IgG. This high level of specificity enables direct analysis of IgG or Fab analytes directly from complex samples such as cell culture supernatants, lysates, or partially purified samples, offer…

Octet® AHQ biosensors provide a rapid method for precise quantitation of human immunoglobulins from crude lysates and cell culture supernatants. Factory immobilization of an anti-human IgG antibody onto the biosensor surface enables direct detection of human IgG analytes with minimal sample handling and facilitates sample quantitation from cell culture screening through downstream purification development.

Octet® ProA biosensors are coated with Protein A and enable rapid antibody quantitation from crude lysates, cell culture supernatants and complex matrices.

Octet® Streptavidin (SA) Biosensors are coated with streptavidin and can be easily customized for various applications, including rapid kinetic analysis, screening and quantitation of most proteins. Octet® SA Biosensors are offered in a tray format. Each tray contains 96 biosensors.

Octet® AMQ biosensors provide a rapid method for precise quantitation of murine immunoglobulins from crude lysates and cell culture supernatants. 

Octet® APS Biosensors are coated with aminopropylsilane and provide a convenient method for hydrophobic based immobilization of most protein analytes for assaying the kinetic profile of protein-protein interactions. 

Octet® SSA (Super Streptavidin) Biosensors offer the highest sensitivity for the demands of small molecule kinetic experiments.

Octet® Anti-Human Fc Capture (AHC) Biosensors are designed for kinetic characterization of interactions between human Fc-containing proteins and target analytes. Octet® AHC Biosensors are offered in a tray format. Each tray contains 96 biosensors. Larger orders include discounts.

Host cell proteins (HCPs) are contaminants found in biopharmaceuticals expressed in bacterial, yeast or mammalian production cell lines. Among protein expression cell lines, Chinese hamster ovary (CHO) cells are the most commonly used mammalian hosts for industrial production of recombinant protein therapeutics. However, manufacturing and production processes of biopharmaceuticals often leave behind contaminating HCPs fr…

Octet® Anti-Mouse Fc Capture (AMC) Biosensors are designed for kinetic characterization of interactions between mouse Fc-containing proteins and target analytes. Octet® AMC Biosensors are offered in a tray format. Each tray contains 96 biosensors.

The Octet® Amine Reactive 2nd Generation (AR2G) Biosensors are designed for EDC/Sulfo-NHS based immobilization of primary amine containing biomolecules and kinetic characterization of their interactions with target analytes. The use of the AR2G Biosensors requires the Amine Coupling Second-Generation Reagent Kit (AR2G Kit, Item no.: 18-5095). Octet® AR2G Biosensors are offered in a tray format. Each tray contains 96 biosensor…

The Octet® Amine Reactive 2nd Generation (AR2G) Biosensors are designed for EDC/Sulfo-NHS based immobilization of primary amine containing biomolecules and kinetic characterization of their interactions with target analytes. The use of the AR2G Biosensors requires the Amine Coupling Second-Generation Reagent Kit (AR2G Kit, Item no.: 18-5095). Octet® AR2G Biosensors are offered in a tray format. Each tray contains 96 biosensor…

The Octet® Anti-HIS (HIS2) Biosensors are designed for label-free quantitation of HIS-tagged proteins. Octet® HIS2 Biosensors are offered in a tray format. Each tray contains 96 biosensors.

Octet® SAX biosensors are high precision streptavidin biosensors that were specifically developed and qualified for applications in drug discovery and quality control labs that have stringent requirements for assay precision and robustness in quantitation and binding kinetics characterization assays.

The polyhistidine protein tag (His-tag), commonly engineered into proteins during cloning, can be used to facilitate recombinant protein purification and detection by exploiting the chelating properties of histidine to an immobilized metal. The Octet® HIS1K Biosensors consist of high affinity, high specificity Penta-His antibody pre-immobilized on a fiber optic biosensor. In conjunction with the Octet® systems, the Octet® HIS…

The Ready BLI Detection Kit - Residual Protein A (RPA) applies the principles of Bio-Layer Interferometry (BLI) to enable sensitive, accurate quantitation of leached Protein A in bioprocess samples while maintaining a simple workflow. The kit utilizes a validated sample treatment method for dissociating Protein A from antibodies that does not require boiling, neutralization, or centrifugation steps.

The Octet® Sialic Acid (GlyS) Kit is designed for a rapid high-throughput relative Sialic Acid content screening during early clone selection stages in Cell Line Development (CLD). The kit allows to conveniently screen and rank both crude and purified mAb and non-mAb protein samples.

Streptavidin-coated surfaces are widely used as a simple and straightforward method of molecular immobilization. Utilized with Bio-Layer Interferometry (BLI), Streptavidin biosensors enable quick and easy modification and customization of the biosensor with any biotin-tagged molecule for quantitative and kinetic measurements. The Octet® SAX2 biosensors are high precision streptavidin biosensors that were specifically develope…