Metabolism Assays Products & Reviews

Cell viability and vitality kit to measure metabolic activity and dead/non-viable nucleated cells with Hoechst to determine total nucleated cell count.

Determine metabolic activity of Lager and Ale yeast.

Exogenous volatile organic compound probes (EVOC Probes) enable targeted, non-invasive assessment of biological pathways. Probes are safe, easy to administer compounds that interact with characterised metabolic pathways with relevance to key disease areas. Using Breath Biopsy, EVOC Probes can be monitored non-invasively on breath, either alone or in parallel with biomarker discovery studies.

CYRIS monitors and analyzes several key cellular parameters in real-time and label-free. Cell viability, metabolism, and morphology can be screened in a fully automated and atmosphere-controlled environment. The incubator integrated solution measures oxygen, pH, and cellular impedance in a multiwell plate and makes through a digital inverse microscope phase-contrast like live-cell images.

The kit is designed to use with Agilent Seahorse XF Pro analyzer for easily identifying drug-induced mitochondrial toxicity, to de-risk your drug pipeline.  It provides high sensitivity and specificity, reducing false positive and false negatives.  It is applicable to screen compound libraries with a throughput of 80 compounds per plate.  Assay performance metrics Z’ of > 0.5 is achievable following our assay workflow. 

A push-button solution to analyze lipid droplet dynamics, label-free.

In 2008 Gentronix launches a new S9 protocol to extend the application of the GreenScreen HC assay to include the detection of genotoxic metabolites. Many pharmaceuticals only present a genotoxicity hazard after metabolism and such chemicals are called pro-mutagens or pro-genotoxins. Generally, although not exclusively, the liver is considered responsible for the “metabolic activation” (MA) of promutagens. However, none of t…

The iNOS Activation Kits measure cytoplasmic induction of the iNOS enzyme via activation of one of the many inflammatory pathways.

BlueScreen HC uses a single cell strain, which permits 8 compounds to be tested across 8 dilutions (2-fold serial), together with untreated and positive controls, in one 96-well microplate. After arraying test compounds and dilutions, growing cells are added to each well. For studies without S9 metabolic activation data are collected after incubation (48h) using a multimode microplate reader. For studies incorporating S9 metab…