Oligonucleotides Products & Reviews

CPG for the incorporation of a 2'-fluoro modified nucleobase at the 3' end of an oligonucleotide

CPG for the incorporation of a 2'-O-methyl modified ribo- nucleobase at the 3' end of an oligonucleotide.

CPG for the incorporation of an (otherwise unmodified) reverse (5' to 3') nucleobase at the 3' end of an oligonucleotide.

CPG used to incorporate the cyanine-5 dye moiety onto the 3'-end of an oligonucleotide.

A phosphoramidite used for 5'-CAL Fluor Red 610 labelling of oligonucleotides.

CPG for the incorporation of a 2'-O-methyl modified ribo-A nucleobase at the 3' end of an oligonucleotide.

CPG for incorporation of a 2'-O-methyl modified ribo-C nucleobase at the 3' end of an oligonucleotide.

CPG for incorporation of unmodified ribo-G at 3' end of an oligonucleotide.

CPG for incorporation of a 2'-O-methyl modified U nucleobase at the 3' end of an oligonucleotide.

CPG for incorporation of GalNAc at 3' end of an oligonucleotide, with a dR spacer.

CPG for the incorporation of cholesterol at 3' end of an oligonucleotide, with a dR spacer.

High-quality and cost-effective custom RNA oligos up to 266 nt, featuring comprehensive modifications.

High-quality and cost-effective custom DNA oligos up to 218 nt, backed by over 22 years of experience.

Semiconductor-based 8 million oligos per chip with superior precision and consistency.

A software platform for analyzing the characteristics of oligonucleotides

Primer and probe pools for the U.S. CDC and and Charité tests.

The Odyssey® Infrared EMSA Kit coupled with IRDye® 700 EMSA oligonucleotides is an excellent alternative method to radioisotopic and chemiluminescent detection methods for EMSA analysis and visualization. Using IRDye EMSA reagents, assays can be completed in less than two hours with no gel transfer or film exposure.

A DNA oligonucleotide end-labeled with IRDye 700 infrared dye is a good substrate for protein binding. Using the Odyssey Infrared Imaging System, IRDye infrared dye labeled DNA detection is linear within a 50-fold dilution range from 9.1 fmol to 0.18 fmol.

Our Metabolite Identification service employs HRMS /LC-MS/MS to decode degradation pathways of antisense oligonucleotides (ASOs), siRNAs, and modified variants, identifying chain-shortened metabolites (5’/3’ cleavage), phosphorothioate changes (desulfurization, inversion) and base/nucleotide alterations (deamination/depurination). Through plasma/tissue/cell analysis, we reveal metabolic stability, biodistribution, and exonucle…

High-quality deoxynucleotide triphosphates (dNTPs) are critical for the success of many key procedures such as cDNA synthesis, sequencing and labeling.   Promega dNTPs have greater than 99% triphosphate content and are provided at a concentration of 100mM in water at pH 7.5. dNTPs Features & Benefits:   Dependable - PCR-tested deoxynucleotides ensure optimal performance with all Promega amplification enzyme…

Modifications that enhance the performance of oligonucleotides

Custom adapters for multiplex next-generation sequencing

Predesigned primers for gene expression analysis

Specialized purification to ensure high performance

Larger quantities for in vivo, high throughput and commercial projects