3D Tracking of Microglial Response to Neuroinflammation

In a healthy body, microglia regularly scavenge the central nervous system looking for plaques, damaged neurons, or infectious agents that need to be cleared. However, when activated by neuroinflammation they change structure and function. These activated cells have been observed in much higher levels at sites of neurodegenerationin patients with neurodegenerative diseases, compared to healthy people. This application note describes the use of Imaris to track and image microglial responses to neuroinflammation in three dimensions.