A comprehensive method for the analysis of pain management drugs

In this application note from Waters Corporation, discover a complete method for the solid phase extraction and UPLC-MS/MS analysis of pain management drugs and drugs of abuse for clinical research. This method optimizes sample preparation to efficiently extract all analytes with a simplified procedure that reduces the number of manual steps. Furthermore, the water wettable nature of the sorbent enables in-well sample pretreatment and direct loading without conditioning and equilibration, eliminating sample transfer and potential transcription errors.