Application of HFX NMR to Facilitate the Complete Assignment of the Anti-fungal Agent Voriconazole

Fluorine is found with an ever-increasing frequency in materials science and in both legal and illicit drugs. This application note presents results to illustrate the simplification afforded by the routine application of triple-resonance NMR to clearly assign voriconazole, a molecule containing proton, carbon, and nitrogen molecules with many atoms exhibiting J-coupling to fluorine.