Assessing Drug Sensitivity and Effects in Complex 3D Tumor Models

Cell viability assays are commonly used in drug discovery to characterize cell responses to endogenous and exogenous factors or substances. However, fluorescence-based cellular assays are becoming increasingly popular, due to their sensitivity and versatility. This application note demonstrates how the combining Tecan’s Infinite M200 PRO with the InSphero’s organotypic microtissue tumor model (which harbors fluorescent reporter proteins) provides a scalable system to assess drug sensitivity in complex 3D cell culture models. The results show that this combination provides a powerful tool to assess drug sensitivity in more complex 3D cell culture models.